introduction: after presbycusis, noise-induced hearing loss is the second most common cause of acquired hearing loss. numerous studies have shown that high-intensity noise exposure increases free radical species; therefore, use of antioxidants to detoxify the free radicals can prevent cellular damage in the cochlea. we studied the potential hearing protective effect of different doses of ascorb...

excessive exposure to noise can lead to noise-induced hearing loss. otoacoustic emissions affect the microscopic biomechanical activities of healthy outer hair cells. the present study aimed at assessing the influence of various sound pressure levels on distortion product otoacoustic emissions (dpoaes) in rats. to this end, 27 adult male rats with an age range of 3 to 4 months and a weight of 2...

conclusions the significant difference between groups 1 and 3 permits to establish a correlation between degree of nicotine addiction and hearing loss. however, further studies are needed to identify the mechanisms leading to hearing loss. patients and methods the study recruited smokers (100) and non-smokers as a reference group (100) aged 21 to 50 years living in noisy or quiet areas of beiru...

patients and methods in this cross-sectional study, 791 infants were recruited via non-random sampling. demographic and clinical characteristics of the subjects were gathered, and the automated auditory brainstem response (aabr) test was performed upon admission. afterwards, the subjects were followed-up and re-assessed, using the aabr test. for infants with abnormal aabr results, the auditory ...

objective: hearing loss is the most frequent neurosensory defect in human. mutations in gjb2 and gjb6 are responsible for 50% of autosomal recessive non-syndromic hearing loss (arnshl) cases. here we report on the frequencies of gjb2 and gjb6 mutations and three large deletions spanning the gjb6 gene including del (gjb6-d13s1830), del (gjb6-d13s1854) and a >920 kb deletion in patients affected ...

PURPOSE Homozygous mutations in SLC4A11 cause 2 rare recessive conditions: congenital hereditary endothelial dystrophy (CHED), affecting the cornea alone, and Harboyan syndrome consisting of corneal dystrophy and sensorineural hearing loss. In addition, adult-onset Fuchs endothelial corneal dystrophy (FECD) is associated with dominant mutations in SLC4A11. In this report, we investigate whether...

We studied a family presenting 10 individuals affected by autosomal dominant deafness in all frequencies and three individuals affected by high frequency hearing loss. Genomic scanning using the 50k Affymetrix microarray technology yielded a Lod Score of 2.1 in chromosome 14 and a Lod Score of 1.9 in chromosome 22. Mapping refinement using microsatellites placed the chromosome 14 candidate regi...

Background. Even if various pathophysiological events have been proposed as explanations, the putative cause of sudden hearing loss remains unclear. Objectives. To investigate and to reveal associations (if any) between the main iron-related gene variants and idiopathic sudden sensorineural hearing loss. Study Design. Case-control study. Materials and Methods. A total of 200 sudden sensorineura...

Non-syndromic hearing impairment is one of the most heterogeneous hereditary conditions, with more than 40 reported gene localisations. We have identified a large Dutch family with autosomal dominant non-syndromic sensorineural hearing impairment. In most patients, the onset of hearing impairment is in the first or second decade of life, with a slow decline in the following decades, which stops...