240 Anesthetic Management of Hereditary Hemorrhagic Telangiectasia in a Parturient Abstract Type: Case Report/Case Series Patrick W. Clark, M.D.; Jamie Murphy, M.D. Johns Hopkins UniversityType: Case Report/Case Series Patrick W. Clark, M.D.; Jamie Murphy, M.D. Johns Hopkins University Introduction: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant condition that is character...

I N THE PROVINCE of V#{228}sterbotten, Ncrth Sweden, we have observed a hitherto undescribed anomaly of erythropoiesis, characterized by : ( 1 ) a nonhemolytic normochromic anemia with a low or normal reticulocyte count and without indications of reduced activity of either granulocytopoiesis or thrombocytopoiesis; ( 2 ) a characteristic bone marrow picture, corresponding to that seen in the di ...

A 53-year-old man presented with sudden onset left-sided weakness. His medical history included hereditary hemorrhagic telangiectasia with recurrent epistaxis. On examination, he was hypoxemic at rest and had left-sided flaccid hemiparesis. He was noted to have multiple lower lip telangiectasias (Figure 1). Computed tomography of chest revealed bilateral segmental and subsegmental pulmonary emb...

Defective paracrine Transforming Growth Factor-β (TGF-β) signaling between endothelial cells and the neighboring mural cells have been thought to lead to the development of vascular lesions that are characteristic of Hereditary Hemorrhagic Telangiectasia (HHT). This review highlights recent progress in our understanding of TGF-β signaling in mural cell recruitment and vessel stabilization and h...

The Brain in Hereditary Hemorrhagic Telangiectasia • While neurological symptoms are often mentioned in reports of families with hereditary hemorrhagic telangiectasia (HHT) and are frequently assumed to be due to vascular anomalies of the central nervous system, documentation of such anomalies is surprisingly rare. Two cases of surgically treated symptomatic cerebral vascular malformations in H...