objective: several vaccines against hiv have been investigated but none has been approved as an effective hiv vaccine. an approach that could induce stronger immune response against the pathogen is utilizing a multi-epitopic vaccine. this strategy was used in the design of several vaccines and resulted in improved immune responses. materials and methods: in this study a multi-epitopic fusion p...

BACKGROUND The unknown primary tumour (UPT) is an intriguing clinical finding in approximately 5% of all newly diagnosed patients with cancer. To evaluate a correlation between the specific immunohistochemical alterations in UPT cells and the unique clinical features of UPT patients, to define the natural history of UPT and to verify prognostic factors, we undertook a detailed clinical and immu...

PURPOSE The aim of this work is to determine the possible relationship between the different profiles of molecular expression of hormone receptors and Her-2÷neu receptors to clinical and histopathological known prognostic variables for breast cancer. MATERIALS AND METHODS A total of 110 breast carcinoma tumor samples were included. In this study 4 groups or immunohistochemical profiles were d...

Basal-like breast carcinoma is characterized by the expression of basal/myoepithelial markers, undifferentiated phenotype, highly aggressive behaviour and frequent triple negative status (ESR-, PR-, Her2neu-). We have previously shown that epithelial-mesenchymal transition (EMT) occurs in basal-like breast tumours and identified Lysyl-oxidase-like 2 (LOXL2) as an EMT player and poor prognosis m...

a random 12 mers phage library was used to screen a pool of immunoglo¬bulin fractions obtained from vitiligo patients. subsequent to panning experiments, a panel of affinity selected phage from vitiligo patients were obtained. this panel was tested using an elis a for their reactivity with pooled sera from patients and normal controls. among the 16 randomly selected clones, two of clones showed...

somatostatin analoges labeled with different radionuclides are able used for imaging and treatment of somatostatin receptor positive tumors. in this study tyr³-octreotide protected at lysine as an analoge of somatostatin was conjugated with bifunctional chelating agent 6-boc-hydrazinopyridine-3-carboxylic acid (boc-hynic) and after deprotecting of conjugate, purification was performed with prep...

Objective: Gallbladder cancer (GBC) is the most common biliary tract malignancy found worldwide with very high incidence in North India especially Delhi region. It characterized by poor prognosis and ineffective treatment advanced stage. The aim of this study was to evaluate EGFR HER2/neu immunoexpression patients correlate it clinicopathological parameters so as identify GBC who can benefit fr...

Ultrasmall gold nanoparticles with a metallic core diameter of 2 nm were surface-conjugated peptides that selectively target epitopes on the surface WW domain model protein hPin1 (hPin1-WW). The binding to was accomplished via thiol group terminal cysteine. particles analyzed by NMR spectroscopy, high-resolution transmission electron microscopy, and differential centrifugal sedimentation. loadi...

Type 1 diabetes mellitus (T1DM) is an autoimmune metabolic disorder characterized by the destruction of pancreatic β‑cells due to reactions autoreactive T‑cells and autoantibodies. The present study aimed investigate association between levels connecting peptide (C‑peptide), several biochemical immunological markers in patients with T1DM treated insulin. For this purpose, a total 5 ml venous bl...

Lung cancer is the leading cause of cancer death in the USA. Approximately 215,020 new cases (114,690 men and 100,330 women) were diag‐ nosed and 161,840 died of lung cancer in 2008 (National Cancer Institute [NCI] 2009). The extremely high lung cancer‐related mortality, demonstrates the limited efficacy of traditional cytotoxic chemotherapy in patients with this disease [1,2]. In the past few ...