Previously we have developed a transgenic zebrafish line (LiPan) with liver-specific red fluorescent protein (DsRed) expression under the fabp10a promoter. Since red fluorescence in the liver greatly facilitates the observation of liver in live LiPan fry, we envision that the LiPan zebrafish may provide a useful tool in analyses of hepatotoxicity based on changes of liver red fluorescence inten...

4. Siemes H, Nau H. Valproate associated hepatotoxicity pathogenesis, clinical aspects, therapy and prevention. Klin Pediatr 1991, 203: 411-419. 5. Dollery Q, Sodium valproate. In: Therapeutic Drugs. London, Churchill Living stone, 1991, pp 563-568. 6. Kondo T, Kaneko S. Otani K, et al. Association between risk factors for valproate hepatotoxicity and altered valproate metabolism. Epilepsia 199...

objectives: acetaminophen (apap) toxicity is known to be common and potentially fatal. this study aims to investigate the protective effects of hydroalcoholic extract, remaining from crocus sativus petals (csp) against apap-induced hepatotoxicity by measuring the blood parameters and studying the histopathology of liver in male rats. materials and methods: wister rats (24) were randomly assigne...

Two patients who developed painless jaundice while taking sulindac are described. Rechallenge in one case confirmed the association of hepatic damage with sulindac administration. Laboratory data and liver biopsy findings suggested a hepatitis with cholestatic features.

persian sturgeon, acipenser persicus is a native, commercially important and highly steemed fish species in the caspian sea. in this study, effects of nodularin (nodln), a cyclic pentapeptide hepatotoxin, on liver and gill tissues of a. persicus were studied. nodularin was produced in high amounts by nodularia spumigena, a cyanobacterium species during the algal bloom in the caspian sea and was...

background & objectives: the present investigation was designed to evaluate the post-treatment properties of the hydroalcoholic fruit extract of cassia fistula (golden shower tree) in male albino mice. materials & methods: biomarkers and histological liver and kidney alterations, aspartate aminotransferase (ast), alanine aminotransferase (alt), alkaline phosphatase (alp), γ-glutamyl tra...

in the present study, protective effect of teucrium polium l. (labiatae) extract on acetaminophen-induced hepatotoxicity was investigated in mice. animals were divided into six groups, each group consist of 8 mice. group one as the negative control group received normal saline, while group two received only crude extract of t. polium l. (500 mg/kg) for five days and group three as the positive ...