Eclipta alba Hassk ( Asteraceae ) having important role in the traditional Ayurvedic, Unani systems of holistic health and herbal medicine of the east. Its main active constituents are wedelolactone, demethylwedelolactone . The important pharmacological activities are Hepatoprotective, Antimicrobial, Antinociceptive, Anti-inflammatory, Analgesic, Immunomodulatory, Antiviral and C.N.S. activity....

BACKGROUND The effectiveness of hepatoprotective drugs for DIH (drug induced hepatotoxicity) during tuberculosis treatment is not clear. We evaluated the effectiveness of hepatoprotective drugs by comparing the period until the normalization of hepatic enzymes between patients who were prescribed with the hepatoprotective drugs after DIH was occurred and patients who were not prescribed with th...

Background: Diethylnitrosamine (DEN) is a hepatotoxin whose metabolic activation by liver cytochromes P450 responsible for the necrosis, mutagenicity and carcinogenicity of cells. The purpose this study was to evaluate protective effects Calotropis procera roots bark against DEN induced hepatocellular damage in rats.
 Material Methods: Hepatoprotective activity ethanolic extract root were ...

BACKGROUND The genus Amaranthus has potential activity as a hepatoprotective agent. OBJECTIVE The present pharmacological investigation focuses on evaluation of the efficacy of aqueous extract of roots of Amaranthus tricolor Linn. for their protection against paracetamol (PCM) overdose induced hepatotoxicity. MATERIALS AND METHODS The aqueous extract of roots of A. tricolor Linn. was prepar...

The hepatoprotective activity of the ethanol extract of Astragalus kahiricus (Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different mechanisms. The extract counteracted the ethanol-induced liver enzymes leakage and glutathione depletion. In addition, it demonstrated anti-apoptotic effects against caspase-3 a...

Methanol and aqueous leaf extracts of L. hirta demonstrated hepatoprotective activity against carbon tetrachloride induced liver damage in rats. The parameters studied were serum total bilirubin, total protein, alanine transaminase, aspartate transaminase and alkaline phosphatase activities. The hepatoprotective activity was also supported by histopathological studies of liver tissue. Results o...

The hepatoprotective activity of ethanolic extract of Wedelia calendulacea L. (Family: Asteraceae) 4 was studied against CCl induced, acute hepatotoxicity in rats. Hepatoprotective activity of the ethanolic-leaf extract of W.calendulacea (EEWC) was studied by estimating serum enzyme activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), prote...

The present study was conducted to evaluate the hepatoprotective activity of hydroalcoholic extract of Tabernaemontana divaricata Linn.against paracetamol induced liver damage in rats. The hydroalcoholic extract of Tabernamontana divaricata Linn. (600mg/kg) was administered orally to the animals with hepatotoxicity induced by paracetamol (3gm/kg). Silymarin (25mg/kg) was given as reference stan...

The ethanol-water extract of A. deliciosa root (EEAD) was fractionated into n-hexane (EEAD-He), ethyl acetate (EEAD-Ea), n-butanol (EEAD-Bu) and aqueous (EEAD-Aq) fractions according to their different polarity and solubility. Among the four extracts, it was found that EEAD-Bu was enriched with oleanolic acid (OLA). The antioxidant and hepatoprotective activities of various EEAD fractions and O...

In the present study, the hepatoprotective activity of hydroalcoholic extract of Selaginella corymbosa leaves was investigated. Qualitative test confirmed the presence of flavonoids, sterols and saponins in the extract. The extract was studied for isoniazid and chloroquine induced hepatic injury using 500mg/kg oral dose in albino rats. The changes were assessed by serum enzyme profile, which in...