BACKGROUND No sequential long-term data exist for Greece on the etiological evolution and incidence of cirrhosis and hepatocellular carcinoma. Therefore, we studied their etiological evolution over a period of 25 years in the island of Crete. METHODS We studied 812 cases of cirrhosis (561 male, median age 69 years) and 321 cases of hepatocellular carcinoma (234 male, median age 70 years) from...

Hepatocellular carcinoma (HCC) remains a major problem in oncology. The molecular mechanisms which underlie its pathogenesis are poorly understood. Recently the Small Heterodimer Partner (SHP), an orphan nuclear receptor, was suggested to be involved as a tumor suppressor in hepatocellular carcinoma development. To date, there are no such studies regarding fibrolamellar carcinoma, a less common...

CONTEXT Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. OBJECTIVE To assess the relationship among human EGF gene single-nucleotide polymorphism, EGF expression, and risk of hepatocellular carcinoma. DESIGN, SETTING, AND PARTICIPANTS Molecular mechanisms linki...

Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are among the most common cancers across the world. Therefore, identifying the potential molecular mechanisms that promote HCC and CRC progression and metastasis are urgently needed. Spermidine/spermine N1-acetyltransferase (SSAT) is a catabolic enzyme that acetylates the high-order polyamines spermine and spermidine, thus decreasing th...

Metastatic adenocarcinoma to the liver from an unidentified primary tumor site is a common diagnostic problem. The present study included 41 cases of histologically diagnosed liver biopsies including hepatocellular carcinoma, cholangiocarcinoma and metastatic carcinoma in the liver. All cases were stained immunohistochemically with Cytokeratin 18, 7, and 20, Carbohydrate Antigen 19-9 and Alpha-...

The increased expression of SIRT1 has recently been identified in numerous human tumors and a possible correlation with c-Myc oncogene has been proposed. However, it remains unclear whether SIRT1 functions as an oncogene or tumor suppressor. We sought to elucidate the role of SIRT1 in liver cancer under the influence of c-Myc and to determine the prognostic significance of SIRT1 and c-Myc expre...

We reviewed the tumor markers for hepatocellular carcinoma, with special reference to the roles of Dickkopf-1 and α-fetoprotein in hepatocellular carcinoma.

Both transforming growth factor-β (TGF-β) and parathyroid hormone-related protein (PTHrP) regulate important cellular processes, such as apoptosis in the development of hepatocellular carcinoma. However, the mechanisms of regulation of PTHrP by TGF-β are largely unknown. We hypothesized that TGF-β regulates the expression of PTHrP protein through a post-translational mechanism. Using hepatocell...

AMA Hříbek P, Klasová J, Tůma T, et al. Invasive measurement of hepatic venous pressure gradient before resection hepatocellular carcinoma. Clinical and Experimental Hepatology - Manuscripts Accepted. 2023. doi:10.5114/ceh.2023.130662. APA Hříbek, P., Klasová, J., Tůma, T., Pudil, Menclová, K., & Mačinga, T. (2023). https://doi.org/10.5114/ceh.2023.130662 Chicago Petr, Johana Tomáš Jiří Kateřin...

Comprehensive analysis of hepatocellular carcinoma 3D models revealed enhanced penetrative siRNA delivery by a nanodiamonds compared to liposomes. Nanodiamonds were able improve siRNA's gene knockdown and anti-cancer effects in tumor models.