It is now clearly established that insulin controls the utilization of glucose by muscle and adipose tissue (l-4), presumably by stimulating glucose transport across an otherwise impermeable cell membrane. Although a similar role of insulin in hepatic glucose uptake seems unlikely, since the liver cell is reported to be freely permeable to both inflow and outflow of glucose (5), there is nevert...

The aim of this study was to investigate the possible effects maternal administration lead acetate on morphological structure liver; AST, ALT, ALP and GGT levels glycogen content hepatocytes male offspring wistar rats. Female rats were exposed 0.2% in drinking water performed their (7 groups). To evaluate liver enzymes, blood samples taken from after anesthesia. After dissection, its hepatocyte...

The activities of several enzymes possibly implicated in lipogenesis were measured in the soluble fraction of homogenates of liver and adipose tissue of embryonic and growing chicks. The activities of adipose-tissue enzymes showed little or no change. The activities of hepatic hexose monophosphate-shunt dehydrogenases, malate dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase and NAD-linked a...

For the first time, a complete study, including fresh and dried aerial parts of Phyllanthus amarus was performed using Guadeloupe's population traditional extraction methods. In this antidiabetic antioxidant activities P. infusion decoction in water with short boiling were evaluated glucose-6-phosphatase enzyme H4IIE hepatic cells inhibition stimulation glucose uptake C2C12 skeletal muscle cell...

Inflammation is a constant in Non-Alcoholic Fatty Liver Disease (NAFLD), although their relationship unclear. In transgenic zebrafish system with chronic systemic overexpression of human IL6 (IL6-OE) we show that inflammation can cause intra-hepatic accumulation triglycerides. Transcriptomics and proteomics analysis the IL6-OE liver revealed deregulation glycolysis/gluconeogenesis pathway, espe...

A body of evidence has accumulated which indicates that the :purine analogue, 8-azaguanine, has an inhibitory action upon protein synthesis. It has been shown in several laboratories that the production of certain inducible bacterial enzymes may be inhibited by this agent (14). It has also been reported by Mandel (5) that utilization of methionine-Ss5 and cystine-S35 for protein synthesis was m...

Studies were performed to determine the effects of an immunopotentiating agent, lentinan, on the hepatic drug-metabolizing enzymes in mice. Lentinan was injected twice a day for two days, and the enzyme activities were determined 12 hr after the last injection of lentinan. A lentinan dose of over 0.25 mg/kg was required to cause a significant decrease (20-40%) in the hepatic microsomal aminopyr...

Previous studies in vivo have demonstrated that in neonatal and adult rats hepatic malic enzyme expression is controlled at the pretranslational level by dietary and hormonal factors [ 1, 21. However, in order to demonstrate that particular effectors have a direct effect on gene expression in liver cells, techniques in vitro, such as the use of primary cultures of non-proliferating rat hepatocy...

Rats injected with carbon tetrachloride show markedly elevated plasma glutamic oxalacetic transaminase and plasma fumarase but, at the same time, these enzyme activities do not decrease in the liver. Three mechanisms are proposed which may account for the increase in plasma enzymes: first, a transfer of the enzyme systems from the necrotized liver cell to the plasma; second, the synthesis of pl...

Activities of drug-metabolizing enzymes (DMEs) are known to change throughout the course of physical and sexual maturation, with the greatest variability noted during infancy and adolescence. The mechanisms responsible for developmental regulation of DME are currently unknown. However, the hormonal changes associated with puberty/adolescence provide a theoretical framework for understanding the...