Splenectomy can treat conditions characterized by hemolysis or thrombocytopenia caused autoantibodies splenic reticuloendothelial function, as well disorders massive splenomegaly and hypersplenism with cytopenias, such hereditary spherocytosis, transfusion-dependent thalassemia, immune thrombocytopenia, autoimmune hemolytic anemia, marginal zone lymph is no longer used for Hodgkin disease stagi...

The risks of transfusion remain significant. Familiarity with the incidence, etiology, management, and prevention of commonly encountered transfusion reactions is integral to the practice of transfusion medicine. This review intends to serve as a practical guide reflecting the current understanding of adverse transfusion events, clinical features helpful for diagnosis, and recommended managemen...

BACKGROUND Although red blood cell (RBC) transfusion represents an integral component of sickle cell disease (SCD) care, transfusion support for some patients can result in alloimmunization to RBC antigens. Alloimmunized patients with SCD appear to experience worse survival compared to nonalloimmunized patients. While this difference in mortality may in part be due to underlying immunologic dif...

Introduction. Hyperhemolysis is characterized by a life-threatening hemolytic transfusion reaction, with hemoglobin (Hb) and hematocrit (Hct) dropping markedly lower than before transfusion. This phenomenon, commonly described in sickle cell disease, is a rare occurrence in patients without hemoglobinopathies. Case Report. A 55-year-old male presented to the hospital after a motorcycle crash an...

By WILLIAM H. CROSBY, MAJOR, MC, AUS P AROXYSMAL nocturnal hemoglobinuria (Marchiafava-Micheli syndrome) is a rare form of chronic hemolytic anemia characterized by the presence of abnormal erythrocytes which are susceptible to lysis by a factor normally present in plasma or serum. It has recently been suggested that this factor resembles closely or may even be identical with the coagulation ac...

We report a patient who showed delayed hemolytic transfusion reaction (DHTR) twice in two weeks due to multiple antibodies anti-C, -e and -Jka. The patient was a 67-year-old male with liver cirrhosis and hepatoma. The first DHTR was observed on day 7 after transfusion of 6 units of red cells for bleeding from gastric varices. Levels of both LDH and total bilirubin were remarkably increased and ...

The aim of this case report is to present the life saving use of extracorporeal membrane oxygenation (ECMO) in an obstetric patient with acute cardiorespiratory collapse following massive bleeding caused by an atonic uterus post partum. A 39-year-old patient, following a spontaneous abortion at 21 weeks of pregnancy, developed uterine atony and massive bleeding and was ultimately referred to th...

By LAWRENCE E. YOUNG, M.D., DONALD M. ERVIN, M.D., AND CHARLES L. YUILE, M.D. H EMOLYTIC transfusion reactions occur more frequently than is generally appreciated and their incidence can be expected to increase for some time as the distribution of blood is facilitated. Many are doubtless overlooked because the outward manifestations may not be particularly striking, especially in anesthetized p...

By LAWRENCE E. YOUNG, M.D., DONALD M. ERVIN, M.D., AND CHARLES L. YUILE, M.D. H EMOLYTIC transfusion reactions occur more frequently than is generally appreciated and their incidence can be expected to increase for some time as the distribution of blood is facilitated. Many are doubtless overlooked because the outward manifestations may not be particularly striking, especially in anesthetized p...

CONTEXT The risk of acquiring babesiosis by blood transfusion is largely unknown since in areas where it is endemic it is often an asymptomatic infection. OBJECTIVE To investigate and treat a cluster of blood transfusion-associated babesiosis cases. DESIGN Case series and epidemiologic investigation. SETTING Urban inner-city hospital. PATIENTS Six persons who received Babesia microti-in...