Dear Editor-in-Chief The recent report on “The Adverse Effects of Pregnancies Complicated by Hemoglobin H (HBH) Disease” is very interesting (1). Rabiee et al. reported a pregnant case complicated with HBH disease. Indeed, this problem might not common in the Middle East but it is very common in Southeast Asia. The authors hereby would like to share the experience on this top...

IFFERENCES IN THE HEMOGLOBINS of the adult and the newborn have been recognized since 1866 (36). Rapid advances in this field, however, began in 1949, when Pauling and Itano (25) discovered that the hemoglobin of sickle cell disease differs from adult hemoglobin. Since that time, 8 hemoglobins have been identified, hemoglobin C (18) in 1950, hemoglobin D (14) in 1951, hemoglobin E (7, 17) and h...

In an English family living in the county of Norfolk, England, Ager, Lehmann, and Vella (2) have described the occurrence of an electrophoretically fast moving variant of human adult hemoglobin (hemoglobin A). This hemoglobin has been named hemoglobin Norfolk. Gammack et al. (3) have reported that hemoglobin Norfolk contains abnormal ac-peptide chains. By a microscale adaptation of the dissocia...

We determined whether addition of hemoglobin to the plasma would inhibit endothelial-dependent dilation in brain where tight endothelial junctions limit hemoglobin extravasation. Pial arteriolar diameter was measured by intravital microscopy through closed cranial windows in anesthetized cats either without transfusion (hematocrit = 32%) or after exchange transfusion with an albumin or sebacyl-...

Haptoglobin-related protein (Hpr) is a primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particles shown to be a part of the innate immune defense. Despite the assumption hitherto that Hpr does not bind to hemoglobin, the present study revealed that recombinant Hpr binds hemoglobin as efficiently as haptoglobin (Hp). However, i...

The association of the isolated cytoplasmic fragment of band 3 protein with human hemoglobin was studied by rate zonal centrifugation in sucrose density gradients, by quenching of fragment fluorescence by hemoglobin, and by flash photolysis of carbon monoxidebound hemoglobin as a function of fragment concentration. The centrifugation results showed that both proteins interact and that the inter...