Fusarium infections are an important problem worldwide, commonly affecting immunocompromised individuals. We conducted a retrospective study in two Israeli tertiary medical centers of factors predisposing to infection by Fusarium spp. and their influence on the epidemiology and clinical outcome of this infection. Fusarium spp. were isolated from 89 patients with a median age of 57 years. Sixty-...

OBJECTIVES To evaluate the epidemiology, risk factors, and antibiotic resistance of Gram negative bacteria (GNB) in patients with hematologic or solid organ malignancies.   METHODS This is a retrospective study of 61 episodes of GNB bacteremia occurring in 56 patients with malignancy admitted to the Oncology Units in King Khalid University Hospital, Riyadh. Kingdom of Saudi Arabia during the ...

Human multiple myeloma (MM) is a presently incurable hematological malignancy, and novel biologically based therapies are urgently needed. Proteasome inhibitors represent a novel potential anticancer therapy. In this study, we demonstrate that the proteasome inhibitor PS-341 directly inhibits proliferation and induces apoptosis of human MM cell lines and freshly isolated patient MM cells; inhib...

Due to non-MHC-restricted and potent cytotoxicity against hematological malignancy, one group of heterogeneous effector T cells with diverse TCR specificities, cytokine-induced killer (CIK) cells are considered as a promising therapeutic approach of leukemia. Recently, it has been found that IL-2/IL-15-activated CIK cells were superior to that of generated with IL-2 protocol, however, the under...

conclusions current study revealed that a. flavus was the most common isolated pathogen. moreover, a. fumigatus was the second common isolated pathogen in patients with ifs. additionally, the hospital construction was an important environmental risk factor for acquisition of infection in patients with hematological malignancy. the most common season for ifs incidence was summer. additionally, t...

Objective: Candidiasis" is the predominant fungal infection that occurs invasively and opportunistically in individuals with compromised immune systems. Febrile neutropenia patients receiving cytotoxic chemotherapy due to malignancy, especially acute leukemia stem cell transplantation are at greater risk among many others. In this study, it was aimed search for Candida DNA make an early diagnos...

Sweet's syndrome (acute febrile neutrophilic dermatosis) is an infrequent skin disease characterized by sudden onset of fever, leucocytosis and erythematous plaques or nodules infiltrated by neutrophils. There are three main clinical settings in which Sweet's syndrome has been described: classical or idiopathic Sweet's syndrome, malignancy-associated Sweet's syndrome and drug-induced Sweet's sy...

Multiple myeloma (MM) is a hematological malignancy characterized by high risk for thrombotic episodes, mainly venous thromboembolism (VTE). This accentuated cancer treatments such as immunomodulatory drugs (IMiDs). Cancer-associated thrombosis one of the leading causes mortality and morbidity, prevention is, therefore, paramount significance. To this day, it unclear which type thromboprophylax...

Background: Febrile neutropenia (FN) is most often caused due to chemotherapy. Solid or certain lymphoproliferative malignancies can increase the duration of hospitalization and other complications in cancer patients. Filgrastim is used in childhood FN management. This study aimed to compare the effect of two different doses of Filgrastim on hematological and paraclinical factors in hospitalize...

Objective: This study aimed to reveal whether immature granulocyte levels can be used for determining the disease activity of rheumatoid arthritis.
 
 Material and Methods: The was conducted in Kastamonu Rehabilitation Center. data 163 patients with arthritis were reviewed retrospectively. Laboratory 92 healthy individuals control group. Complete blood cell counts, measurement erythro...