Parasitic infectious diseases like malaria and certain hereditary hematologic disorders are often associated with major changes in the shape and viscoelastic properties of red blood cells. Such changes can disrupt blood flow and, possibly, brain perfusion, as in the case of cerebral malaria. In recent work on stochastic multiscale models—in conjunction with large-scale parallel computing—we wer...

R ETINAL LESIONS have been observed in hematologic diseases since Liebreicil’ described leukemic retinitis in 1861. Most of the literature has been written from the descriptive viewpoint, emphasizing the morphologic appearance of the lesions as an aid in differential diagnosis, rather than the underlying pathophysiology. The present investigation aims to answer the following questions : ( 1 ) W...

Leptin is an adipocyte-derived cytokine coded by the obese gene, not only regulates metabolism, but also participates in hematopoiesis. Aberrant leptin levels in patients with hematologic malignancies were observed and associates with clinical characters, such as body mass index (BMI), gender, blast cell percentage. Leptin concentrations alter while diseases progress or remission. Leptin recept...

Mastocytosis is a myeloproliferative neoplasm characterized by clonal expansion of abnormal mast cells, ranging from the cutaneous forms of the disease to mast cell leukemia. In a significant proportion of patients, systemic mastocytosis (SM) coexists with another hematologic malignancy, termed systemic mastocytosis with an associated hematologic nonmast cell lineage disorder (SM-AHNMD). Despit...

OBJECTIVES Epidemiologic studies suggest an association between environmental exposure to benzene and hematologic cancers, but the relationship is not firmly established. The aim of this study was to assess the potential association between residence near hazardous waste sites containing benzene and hospitalization discharge rates for persons having hematologic cancers. MATERIALS AND METHODS ...

background and objectives: bone marrow necrosis (bmn) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. this study was performed to identify frequency and the underlying associated diseases of marrow necrosis. materials and methods: in this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the pathology depa...

A 75-year-old man with a 5-year history of myelodysplastic syndrome (MDS) subsequently developed worsening fatigue, dizziness, and dyspnea on exertion. There was no family history of hematologic diseases. On examination he was cachectic with no hepatosplenomegaly and petechiae, but purpuric lesions were present on his hands. The complete blood count showed pancytopenia (hemoglobin 10.2 g/dL, wh...