Background. The efficacy, safety, and cost benefit of olanzapine (OLN) when compared to aprepitant (APR) in the prevention of chemotherapy induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC) were evaluated. Methods. A prospective pilot study was done in chemotherapy-naive patients receiving HEC to compare OLN versus APR along with palonosetron and dexam...

Purpose: The purpose of this study is to evaluate HER-2 and topoisomerase II (topo II ) as candidates for predicting the activity of anthracyclines in the adjuvant treatment of breast cancer patients. Experimental Design: In this study, we evaluated HER-2 and topo II gene aberrations by fluorescence in situ hybridization in a series of 430 primary breast cancer samples. Samples came from node-p...

Abstract The present study evaluated the potential of carrot ( Daucus carota L.) leaf, a non-edible part carrots, which are among most consumed vegetables worldwide. antioxidant activities 70% ethanol extract (EEC) and hot water (HEC) leaves were compared. results revealed that total polyphenol content, flavonoid DPPH ABTS radical scavenging higher in EEC than HEC. Both extracts protected cells...

Proper insulin homeostasis appears critical for adapting to and surviving a heat load. Further, heat stress (HS) induces phenotypic changes in livestock that suggest an increase in insulin action. The current study objective was to evaluate the effects of HS on whole-body insulin sensitivity. Female pigs (57 ± 4 kg body weight) were subjected to two experimental periods. During period 1, all pi...

Geographic Information Systems (GIS) are an efficient and interactive spatial decision support tool for flood risk analysis. This paper describes the development of ArcView GIS extension — namely AVHEC-6.avx — to integrate the HEC-6 hydraulic model within GIS environment. The extension was written in an Avenue Script language and Dialog Designer with a series of ‘point and click’ options. It ha...

The diverse mechanism of antimicrobial activity of Ag and AgBr nanoparticles against gram-positive and gram-negative bacteria and also against several strains of candida was explored in this study. The AgBr nanoparticles (NPs) were prepared by simple precipitation of silver nitrate by potassium bromide in the presence of stabilizing polymers. The used polymers (PEG, PVP, PVA, and HEC) influence...

Extracellular superoxide dismutase (EC-SOD) is the only enzyme that removes superoxide radical in the extracellular space. The reduction of EC-SOD is linked to many diseases, suggesting that the protein may have therapeutic value. EC-SOD is reported to be insoluble and to make inclusion bodies when overexpressed in the cytoplasm of Escherichia coli. The refolding process has the advantage of hi...

Objective: To explore the role of RASSF1A in the occurrence and development of endometrial cancer. Methods: In vitro experiments used human endometrial cancer cells (HEC-1-B) treated with different concentrations of 5-AZA-2’-deoxy cytidine (5-Aza-CdR). In vivo experiments used HEC-1-B-treated mice that were exposed to combinations of cisplatin (DDP), medroxyprogesterone acetate (MCP), and/or 5-...

High-mobility group box protein 1 (HMGB1), a nuclear protein that plays a significant role in DNA architecture and transcription, was correlated with the progression of some types of cancer. However, the role of HMGB1 in endometrial cancer cell invasion and metastasis remains unexplored. HMGB1 expression was initially assessed by immunohistochemistry and reverse transcription-quantitative polym...