Introduction In fracture healing mesenchymal stem cells (MSCs) infiltrate the wound site, proliferate extensively and differentiate along a cartilaginous or an osteogenic lineage in response to local environmental cues. The mechanical environment within a fracture callus may regulate endochondral ossification during fracture healing in one of two ways. Firstly, the biophysical stimuli, such as ...

Abstract Concrete structures suffer from cracking that leads to deterioration and shortening of service life. This is very critical for underwater structures, i.e., immersed bridge piles, tunnel or submerged floating tunnels, which are consistently susceptible ingress harmful ions (chloride, sulphate carbonate ions). Autonomous healing concrete cracks can be beneficial assure durability perform...

The stomach is generally regarded as an environment that is not conducive to bacterial colonization. In this study, we examined the possibility that this changes significantly when an ulcer has formed and that colonization of ulcers interferes with the normal healing process. Gastric ulcers were induced by serosal application of acetic acid. The relationship between ulcer healing and bacterial ...

A BSTRACT : Disrupted vasculature and high energy-demand by regenerating tissue results in wound hypoxia. Wound repair may be facilitated by oxygen therapy. Evidence supporting the mode of action of hyperbaric oxygen in promoting wound healing is sketchy, however. Topical oxygen therapy involves local administration of pure oxygen. The advantages of topical oxygen therapy include low cost, the ...

Wound healing in the oral cavity occurs in a bacteria-rich environment, which may affect its outcome. Furthermore, it takes place where forces are frequently applied to the healing tissue. The effect of bacterial endotoxin on the development of tensile strength in healing wounds was studied using surgical skin wounds in rats as a model. Collagen membranes soaked with 0.01 microg of bacterial en...

Wound healing is a highly complex biological process composed of three overlapping phases: inflammation, proliferation, and remodeling. Impairments at any one or more of these stages can lead to compromised healing. MicroRNAs (miRs) are non-coding RNAs that act as post-transcriptional regulators of multiple proteins and associated pathways. Thus, identification of the appropriate miR involved i...

Abstract First of all, we will provide a brief background on the self-healing hydrogels produced which are suitable for complex environment nature. In this paper, disulfide bonds and acylhydrazone can be combined in SH-WPU hydrogen existed PAMAM. And hydrogel achieve under acid, alkaline, neutral or light environment.Self-healing 1 h, 24 h 48 efficiency is 31.58%, 49.84% 87.35% respectively. Th...

Vocal fold epithelial cells likely play an important, yet currently poorly defined, role in healing following injury, irritation and inflammation. In the present study, we sought to identify a possible role for growth factors, epidermal growth factor (EGF) and transforming growth factor-beta 1 (TGFβ1), in epithelial regeneration during wound healing as a necessary first step for uncovering pote...

INTRODUCTION While tissue hypoxia is known to play a critical role in the process of vascular injury and repair, the effect of hypercapnia on this process remains uncertain. We investigated whether hypercapnia might influence endothelial cell wound healing under the influence of hypoxia. MATERIALS AND METHODOLOGY Monolayers of human umbilical venous endothelial cells (HUVECs) were scratch-wou...

Vitamin A and its active forms (retinoic acids/RAs) are known to have pro-healing properties, but their mechanisms of action are still poorly understood. This work aimed to identify the cellular and molecular processes by which atRA (all-trans RA) improves wound healing, using an in vivo model of mouse corneal alkali burns and an in vitro cellular human corneal epithelial injury model. Regulati...