OBJECTIVE The objective of the study was to determine whether the addition of postdischarge oral secobarbital to standard emergency department (ED) migraine headache therapy improves pain relief and headache resolution compared with placebo. SETTING The setting is an urban ED with 70 000 yearly visits. METHODS This is an Institutional Review Board-approved, randomized, nonconsecutive, doubl...

OBJECTIVE Our objective was to assess the safety, feasibility, and effects of the standardized 8-week mindfulness-based stress reduction (MBSR) course in adults with migraines. BACKGROUND Stress is a well-known trigger for headaches. Research supports the general benefits of mind/body interventions for migraines, but there are few rigorous studies supporting the use of specific standardized i...

background: migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. the aim of this study was to investigate the association of a migraine without aura and ala379val polymorphism of lipoprotein-associated phospholipase a2 (lp-pla2) gene in the iranian population. methods: in this study, 103 migraine patients and 100 healthy controls were enrolled. dna samples ...

Effective long-term management of patients with headaches can be challenging because these disorders are complex with heterogeneous triggers, expression, and impact.1,2 While the biomedical model has led to important discoveries in the pathophysiological mechanisms of headache, the model has limitations, including the marked varied individual responses to identical treatments.1 Headache has bot...

BACKGROUND Chronic daily headache (CDH) in children has been documented in general and clinical populations. Comorbid psychological conditions, risk factors and functional outcomes of CDH in children are not well understood. OBJECTIVES To examine anxiety and depression, associated risk factors and school outcomes in a clinical population of youth with CDH compared with youth with episodic hea...

Headaches in children and adolescents are still under-diagnosed. 75% of children are affected by primary headache by the age of 15 with 28% fitting the ICHD2 criteria of migraine. Migraine is considered a chronic disorder that can severely impact a child's daily activities, including schooling and socializing. Early recognition and aggressive therapy, with acute and prophylactic treatments, as ...

Abstract Background The prevalence of primary headache in patients with systemic lupus erythematosus (SLE) varies widely and whether it should be attributed to neurological involvement is controversial. We aimed investigate the characteristics SLE patients, describe its association disease-related variables brain imaging, explore impact on life. Results overall was 54.4%, migraine most common t...

Chronic daily headache (CDH) is a descriptive term that encompasses multiple headache diagnoses and affects approximately 4% of the general adult population. Chronic daily headache results in significant pain and suffering with substantial impact on quality of life, and enormous economic costs to society. Although most patients with primary CDH suffer from chronic migraine or chronic tension-ty...