Squamous cell carcinomas of head and neck (HNSCC) are a result of multiple genetic and epigenetic alterations. Epigenetic inactivation of tumor suppressor genes is an important event in head and neck carcinogenesis. Here we analyzed the promoter methylation of 15 genes (RASSF1A, p16, MGMT, DAPK, RARbeta, MLH1, CDH1, GSTP1, RASSF2, RASSF4, RASSF5, MST1, MST2, LATS1, LATS2) in 54 HNSCC and in mat...

Introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50% -60%. CD44 has been shown to be associated with the prognosis.  Materials and Methods: Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody.  Results: There was no significant correlatio...

نم أشنت .ةردان ةديمح ماروأ يه )ةيفيللا( ةيطابرلا مارولأا عباط تاذ يهو .مسلجا ءاحنأ عيمج يف ةيلضعلا لكايهلا لدعم عافترا ىلإ ىدأ امم ، ةرواجلما هيللمحا ةجسنلأل يحاشترا ةردنل ًارظن و .يحارلجا لاصئتسلاا دعب مرولا عوجر ةبسنو نع غلابلإاب انمق اننإف ، ةبقرلاو سأرلا ةقطنم يف مارولأا هذه يف اهجلاعو قنعلا ىلعأ يف يطابرلا مرولاب اهصيخشت تم ةلاح جلاعل هرفوتلما تارايلخاو قرطلا لوح يعولا ةدايزل ،انافشتسم .ةبق...

Field cancerization predisposes the upper aerodigestive tract mucosa to the formation of multiple primary tumors, when exposed to environmental carcinogens. Up-regulation of epidermal growth factor receptor occurs early in squamous cell carcinogenesis and is critical for the loss of growth control in a variety of human cancers, including head and neck squamous cell carcinomas. In these tumor ce...

PURPOSE Renal cell carcinoma (RCC) is a malignant tumor that metastasizes early, and patients often present with metastatic disease at the time of diagnosis. The aim of our evaluation was to assess the diagnostic and differential diagnostic relevance of metastatic renal cell carcinoma (RCC) with particular emphasis on head and neck manifestations in a large patient series. PATIENTS AND METHOD...

background and objective: fine needle aspiration cytology (fnac) is well accepted as a useful diagnostic technique in the management of adult patients with head and neck lumps. but, until recently, very few reports have been obtained regarding the role of fnac in nonthyroidal neck masses in children. hence, the objective of our study was to determine the diagnostic value of fine needle aspirati...

The frequent loss or promoter methylation of the tumor suppressor gene p16 in head and neck cancer suggests an etiologic role of p16 in this disease. Two adjacent polymorphisms of p16 exon 3, C540G and C580T, were identified recently. C540G is associated with low expression of p53, and both polymorphisms are associated with tumor aggressiveness, suggesting a possible functional relevance. We hy...

The presence and clinical significance of interleukin (IL)-17 and IL-17-expressing cells have recently been studied in several types of cancer, but their correlation to tumor development remains controversial. Additionally, the contribution of peripheral IL-17-expressing cells to head and neck cancer (HNC) progression is still poorly understood. We collected peripheral blood from healthy donors...