INTRODUCTION A decreased serum high density lipoprotein-cholesterol (HDL-C) is a strong predictor of cardiovascular risk. However, total HDL is a very dynamic, changeable fraction, and does not perform the function of atherosclerosis markers. In the presented study, the pattern of serum lipids, including HDL-C subclasses (HDL2- and HDL3-cholesterol), in a middle- aged Polish Lower Silesia popul...

In this study we determined in vivo conversions of human ’H-labeled cholesteryl ester-labeled HDL3 ([’HICEHDLs) in male rats and the effects of partially purified lipid transfer protein on the conversion processes. Zonal centrifugation techniques were used to prepare the [’HICE-HDLS and to follow the conversion processes. One hour after the injection, a complete conversion of HDLs to and HDL,-d...

class HDL2 particles and raised serum apolipoprotein B concentrations. Xanthomata and xanthelasma may relate to low lipoprotein lipase activity (10–12). On a similar theme further questions that need clarity are what about other skin ‘lipid’ stigmata and cardiovascular risk? For example eruptive and tuberous xanthomata are associated with chylomicron syndrome and type III dyslipoproteinaemia, r...

Recent interest in the putative protective role of high-density lipoprotein (HDL) and its subfractions against atherosclerosis has highlighted the need for a rapid, simple subfractionation procedure. Here we compared HDL subfractionation by two recently developed polyanionic-precipitation methods with the values obtained by rate zonal ultracentrifugation. A similar result for total HDL choleste...

In an investigation of alterations in cholesterol metabolism during contraceptive steroid use, we studied plasma clearance of chylomicron remnants. Six healthy women were studied on and off contraceptive steroid therapy. Remnant clearance was measured from the disappearance of retinyl palmitate administered intravenously in plasma endogenously labeled with retinyl palmitate. We also measured ch...

We estimated the effects of breast- and formula-feeding on cholesterol and bile acid metabolism for 1.5 years after weaning in 35 newborn baboons that were breast-fed (n = 12) or fed one of two formulas with high (n = 11) or low (n = 12) polyunsaturated/saturated (P/S) fatty acid composition. Infants were weaned at 15 weeks to a high cholesterol, saturated fat diet. Because formula P/S ratio di...