Identifying mineralization zones is a critical component of quantifying the distribution target minerals using well-established mineral resource estimation techniques. Domains are used to define these and can be modelled techniques such as manual interpretation, implicit modelling, advanced geostatistical methods. In practise, domaining commonly exercise that labour-intensive prone subjective j...

Background: Several studies have suggested that online hemodiafiltration (OL-HDF) may reduce the risk of mortality and improve quality life these patients compared with standard hemodialysis. Methods: Forty stable out on dialysis (20 hemodialysis 20 hemodiafiltration) above age 18 years vintage more than 3 months were followed up for months. Clinical, biochemical parameters along SF-36 score at...

Statistical analysis of the unresolved light in the Hubble Deep Field (HDF) strongly constrains possible sources of the optical Extragalactic Background Light (EBL). This constraint is crucial for determining the spectrum of the EBL because reported upper limits on the optical EBL are several times larger than the surface brightness from detected galaxies, suggesting the possibility of addition...

Sir, We read with much interest the article from Ficheux et al. [1] that appeared in advance access in Nephrology Dialysis and Transplantation on 8 September 2010. The paper describes a parabolic relationship between ultrafiltration coefficient (KUF) and ultrafiltration rate (QUF). The falling KUF with increasing QUF is due to blood protein boundary effects (protein cake effect) and increased r...

The aim of this study was to determine the apoptotic effects, toxicity, and radiosensitization of total low dose irradiation delivered at a high dose rate in vitro to melanoma cells, normal human epidermal melanocytes (HEM), or normal human dermal fibroblasts (HDF) and to study the effect of mitochondrial inhibition in combination with radiation to enhance apoptosis in melanoma cells. Cells irr...

BACKGROUND Strict control of serum calcium and phosphate concentrations is paramount to prevent secondary hyperparathyroidism in haemodialysis (HD) patients. Standard intermittent low-flux HD (Lf-HD) is not sufficient to reach this goal. The aim of this study was to evaluate the effect of on-line haemodiafiltration (Ol-HDF) on serum calcium (sCa), phosphate (sPO4) and parathyroid hormone (PTHin...

Hemodiafiltration (HDF) with 20-22 L of substitution fluid is increasingly recognized as associated with significant benefits regarding patient outcome. However, some doubt exists as to whether these high volumes can be achieved in routine clinical practice. A total of 4176 sessions with 366 patients on postdilution HDF were analyzed in this 1-month observational cohort study with prospective d...

BACKGROUND The heparin requirement for coupled plasma filtration adsorption (CPFA) is usually high. Heparin administration often cannot be adherent to prescription, leading to a premature clotting of circuit and an insufficient volume of treated plasma. Regional citrate anticoagulation (RCA) could be an attractive alternative; however, no data are available on citrate pharmacokinetics at high l...

TGFbeta induces fibrogenic responses in fibroblasts. Reactive oxygen species (ROS)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) may contribute to fibrogenic responses. Here, we examine if the antioxidant N-acetylcysteine (NAC), the NOX inhibitor diphenyleneiodonium (DPI) and the selective NOX1/NOX4 inhibitor GKT-137831 impairs the ability of TGFbeta to induce profibrotic ge...