نتایج جستجو برای: hcv genome

تعداد نتایج: 249841  

Journal: :Annals of hepatology 2007
Laura Trejo-Avila Regina Elizondo-González Karina Del C Trujillo-Murillo Pablo Zapata-Benavides Cristina Rodríguez-Padilla Ana María Rivas-Estilla

BACKGROUND Hepatitis C virus (HCV) is a major public health problem with 170 million chronically infected people throughout the world. Currently, the only treatment available consists of a combination of pegylated interferon (INF-alpha) and ribavirin, but only half of the patients treated show a sufficient antiviral response. Thus there is a great need for the development of new treatments for ...

2015
François M. J. Lamoury Brendan Jacka Sofia Bartlett Rowena A. Bull Arthur Wong Janaki Amin Janke Schinkel Art F. Poon Gail V. Matthews Jason Grebely Gregory J. Dore Tanya L. Applegate Jean-Pierre Vartanian

Sequencing is important for understanding the molecular epidemiology and viral evolution of hepatitis C virus (HCV) infection. To date, there is little standardisation among sequencing protocols, in-part due to the high genetic diversity that is observed within HCV. This study aimed to develop a novel, practical sequencing protocol that covered both conserved and variable regions of the viral g...

2012
Jennifer Ng Jennifer Wu

CONTEXT Hepatitis B and Hepatitis C (HBV and HCV) infections are both major causes of hepatocellular carcinoma (HCC). However, HCC caused by each of these two viruses has unique characteristics that should be studied independently to that of another one. While HBV- and HCV-related HCCs share similar host and environmental risk factors such as male gender, age above 50 years old, family history ...

2013
Alok Upadhyay Updesh Dixit Dinesh Manvar Nootan Chaturvedi Virendra N. Pandey

Hepatitis C virus (HCV) infection leading to chronic hepatitis is a major factor in the causation of liver cirrhosis, hepatocellular carcinoma, and liver failure. This process may involve the interplay of various host cell factors, as well as the interaction of these factors with viral RNA and proteins. We report a novel strategy using a sequencespecific biotinylated peptide nucleic acid (PNA)-...

2005
W. MICHAEL MCDONNELL MICHAEL R. LUCEY

Background. There is a high prevalence of liver disease among the recipients of organs from donors with antibodies to hepatitis C virus (HCV). We undertook a study to determine the frequency of persistent HCV infection, as indicated by the presence of HCV RNA, among both cadaveric organ donors positive for antibodies to HCV (anti-HCV) and the recipients of organs from these donors. Methods. Ser...

Journal: :Gastroenterology 2013
Yuichi Abe Hussein Hassan Aly Nobuhiko Hiraga Michio Imamura Takaji Wakita Kunitada Shimotohno Kazuaki Chayama Makoto Hijikata

BACKGROUND & AIMS A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS We compared gene expression profiles of HuS-E/2 cells cultured under 2-dimensional and ...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996
F Fabrizi G Lunghi I Guarnori L Raffaele G Erba A Pagano F Locatelli

BACKGROUND Hepatitis C virus (HCV) infection is highly prevalent in dialysis patients. To further characterize HCV infection in this patient population, we studied the distribution of viral genotypes in 55 patients undergoing chronic dialysis treatment with seropositivity for HCV markers. METHODS Thirty-two of 55 (58%) patients showed HCV RNA in the serum using reverse transcription polymeras...

Journal: :The Journal of infectious diseases 2001
J J Goedert A Hatzakis K E Sherman M E Eyster

In hepatitis C virus (HCV) infection, virus load and the risk for HCV-related end-stage liver disease (ESLD) are increased among persons with human immunodeficiency virus (HIV) coinfection. To clarify these relationships, 42 hemophilic patients who developed ESLD and random samples from 164 hemophilic patients with HCV infection alone and 146 with HCV-HIV coinfection were tested for HCV load an...

Journal: :jundishapur journal of microbiology 0
faraz salehi moghadam gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran; department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran seyed reza mohebbi gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran; 7th floor of taleghani hospital, velenjak, tehran, ir iran. tel.: +98-2122432514, fax: +98-2122432515 seyed masoud hosseini department of microbiology, faculty of biological sciences, shahid beheshti university, tehran, ir iran hanieh mirtalebi gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran sara romani gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran pedram azimzadeh gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, ir iran

the patient was infected with hcv subtype 6a. prior to this case, there have been no previous reports on the isolation of this genotype/subtype from any other iranian patient. previous epidemiological studies provide valuable information about the distribution patterns of different hcv genotypes. however, infection with genotypes other than common ones should be flagged by specialists and diagn...

Journal: :Canadian journal of public health = Revue canadienne de sante publique 2003
Shimian Zou Leslie Forrester Antonio Giulivi

Hepatitis C virus The identification of the viral genome over 10 years ago rapidly led to the delineation of the genome organization and the structural and biochemical characterization of several viral proteins. However, studies of the viral life cycle, inhibition or inactivation of the virus as well as the development of vaccines or antiviral drugs have been difficult because of the lack of a ...

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