OBJECTIVE To evaluate lung functional capacity (FC) for physical exercise in children and adolescents with sickle cell disease (SCD) through the six-minute walk test (6MWT). METHOD A cross-sectional prospective study was performed to evaluate the FC of 46 patients with SCD through the 6MWT. The following parameters were assessed: heart rate (HR), respiratory rate (RR), peripheral pulse oxygen...

Children with sickle cell anemia (HbSS) are at high risk for neurologically overt cerebral infarcts associated with stroke and neurologically silent cerebral infarcts correlated with neuropsychometric deficit. We used complete magnetic resonance imaging (MRI) histories from 266 HbSS children, aged 6 through 19 years, who were enrolled in the Cooperative Study of Sickle Cell Disease (CSSCD) to e...

Background and Objectives Mesenchymal stromal cells (MSCs) have great therapeutic potential, particularly in the process of tissue repair and immunomodulation through the secretion of biomolecules. Thus, the aim of this study was to evaluate the hypothesis that intramuscular transplantation of allogeneic MSCs obtained from equine umbilical cord (UC-MSCs) is safe, demonstrating that this is a su...

ABSTRACT. Functional graded magnesium matrix composites (FGMMCs) are widely employed for biomedical, aerospace and thermal barrier applications because of their better mechanical properties, biocompatibility bioactivity. In this study, AZ91D-wt. %Ti (x = 0, 4, 8, 12 16) fabricated by ex-situ centrifugal casting method. The NaCl based solution is sprayed on all 72 hours at the 1 kg/cm3 pressure ...

We have investigated the effects of a novel neutrophil-activating factor released by Trichomonas vaginalis (TV-NAF) on neutrophil chemotaxis. TV-NAF was present in the supernatant from 10(7) T. vaginalis (STV) cultured in 1 ml of serum-free Hanks' balanced salt solution (HBSS) at 37 degrees C for 30 min. With a multichamber chemotactic assay, we found that there were 112 +/- 15 migrated neutrop...

BACKGROUND AND OBJECTIVES We investigated outcomes in a UK neonatal cohort as a benchmark for care of children with sickle cell disease (SCD). DESIGN AND METHODS Two-hundred and fifty-two children (180 with hemoglobin [Hb] SS, 64 with HbSC, and 8 with HbS/beta thalassemia), identified during 1983-2005 by universal birth screening in East London, were followed in a hospital and community-based...

The transformation of less-dense, discoidal homozygous sickle cells (HbSS) RBCs into dehydrated, rheologically impaired cells is believed to be an important factor in the pathophysiology of sickle cell disease. We investigated this process by subjecting the less-dense fraction of HbSS RBCs, which contains a low percentage of irreversibly sickled cells (ISCs), to cyclic deoxygenation-reoxygenati...

Background. Risk factors for non-tuberculous mycobacteria (NTM) lung infections have been well investigated. However, few studies have examined risk factors for NTM in-dwelling vascular catheter (IDVC) infections. Sickle cell anemia is known to affect several aspects of the immune system leading to relative immune deficiency. The purpose of this retrospective nested case-control study is to det...