BACKGROUND The underlying mechanism of HBsAg-negative hepatitis B virus (HBV) infection is notoriously difficult to elucidate because of the extremely low DNA levels which define the condition. We used a highly efficient amplification method to overcome this obstacle and achieved our aim which was to identify specific mutations or sequence variations associated with this entity. METHODS A tot...

BACKGROUND Long-term treatment of chronic hepatitis B (CHB) with nucleos(t)ide analogs results in the emergence of drug-resistant hepatitis B virus (HBV) harboring mutations in the polymerase (P) gene. The Phyllanthus extract has anti-HBV activity; however, its antiviral activity against lamivudine (LMV)-resistant mutants has not been examined. METHODS HBV harboring LMV-resistant mutations (r...

Hepatitis adalah penyakit peradangan pada hati yang disebabkan oleh virus, bakteri, dan parasit. tersering infeksi virus B. Prevalensi B di Indonesia sebesar 1,2 % dinyatakan sebagai negara endemik B, sehingga setiap WNI akan bepergian keluar negeri untuk menjadi tenaga kerja (TKI) wajib melakukan pemeriksaan sesuai dengan peraturan ditetapkan Departemen Ketenagakerjaan. Pemeriksaan serologi st...

BACKGROUND There are around 350 million of hepatitis B surface antigen (HBsAg) carriers worldwide, and among them, high risk of developing hepatocellular carcinoma (HCC) has been identified by epidemiological studies. To date, the molecular role of HBsAg in HCC development has not been fully studied. We have previously reported that in cell cultures, HBsAg up-regulated the expression of lymphoi...

OBJECTIVE The purpose of this study was to determine the association between PD1 expression and the clinical prognosis of diffuse large B-cell lymphoma (DLBCL) co-occurring with hepatitis B virus (HBV) infection. METHODS A total of 165 patients presented with newly diagnosed and untreated DLBCL at the First Hospital of Jilin University, Changchun, China, between 2011.01 and 2014.12. Complete ...

background chronic hepatitis b consists of different clinical phases. laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management. objectives this study was conducted to determine laboratory and histological characteristics of hbeag-negative and hbeag-positive chronic hepatitis b patients. patients and methods in this stu...

background: hepatitis b is considered as one of the most common infectious diseases. the contamination of this virus has caused hygienic problems all over the world. liver cirrhosis and hepatocellular carcinoma are most important consequences of this disease. the purpose of this study is to determine the rate of infection in tabriz north west of iran. m aterials and methods: this study is carri...

To determine the clinical implications of HBSAg in severe chronic active liver disease (CALD), patients with HBSAg positive CALD were compared with those chosen by identical clinical, functional, and morphological criteria in whom this test and anti-HBS were negative. HBSAg positive patients were predominantly males over 40 years of age and more frequently failed to respond to conventional trea...