INTRODUCTION The treatment of patients with type 2 diabetes uncontrolled on basal insulin and oral glucose-lowering drugs was investigated previously in the LixiLan-L trial. In the LixiLan-L trial, patients experienced a 6-week run-in with insulin glargine U100 (iGlar) as part of the screening phase, followed by treatment with a fixed-ratio combination of iGlar + lixisenatide (iGlarLixi) or iGl...

OBJECTIVE We previously showed that in patients with diabetes mellitus, glycated hemoglobin (HbA1c) monitoring outside international guidance on testing frequency is widespread. Here we examined the relationship between testing frequency and diabetes control to test the hypothesis that retest interval is linked to change in HbA1c level. RESEARCH DESIGN AND METHODS We examined repeat HbA1c tes...

OBJECTIVE To determine if a laboratory data report (the HbA1c Tracking Tool) could be used as an effective intervention to improve diabetes management. DESIGN A longitudinal quasi-experimental cohort design was used to test the effectiveness of an HbA1c summary report sent to primary care physicians for all patients having HbA1c levels greater than 7%. SETTING Moncton, New Brunswick, Canada...

OBJECTIVE To determine whether self monitoring, alone or with instruction in incorporating the results into self care, is more effective than usual care in improving glycaemic control in non-insulin treated patients with type 2 diabetes. DESIGN Three arm, open, parallel group randomised trial. SETTING 48 general practices in Oxfordshire and South Yorkshire. PARTICIPANTS 453 patients with ...

PURPOSE We studied the changes in subtypes of diabetes mellitus (DM) in children and evaluated the characteristics of each group over the past 20 years. In addition, we also examined the correlation between the glycated hemoglobin (HbA1c) values at the time of diagnosis and lipid profiles. METHODS The patients were divided into 2 groups: there were a total of 190 patients under 20 years of ag...

The present study was designed to examine the role of socioeconomic status (SES) of the mother's knowledge about different aspects of diabetes and the glycemic control of type 1 children with diabetes. Samples were taken from successive admissions to the outpatient diabetes clinics in Prince Sultan Medical Military City (PSMMC), Riyadh, Saudi Arabia. A well designed questionnaire covering diffe...

OBJECTIVE To investigate the dose-response relationship of semaglutide versus placebo and open-label liraglutide in terms of glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS This was a 12-week, randomized, double-blind phase 2 trial. Patients (n = 415) were randomized to receive a subcutaneous injection of semaglutide once weekly without dose escalation (0.1-0.8 ...

Glycosylated hemoglobin (HbA1C) level is a commonly used laboratory investigation in diabetes patients, which reflects glycemic control over a period of 3 months. In various instances, HbA1C levels may be falsely low leading to suboptimal management of diabetes. One such example is the use of dapsone, which is an antibiotic, commonly used to treat various conditions such as leprosy, acne, ulcer...

Background: Diabetes Mellitus (DM) has become a major health problem worldwide. American Diabetes Association has considered HbA1C levels ≤ 6.5 % as the prime target for glycemic control and as a diagnostic criterion for DM. Anemia is common in DM (8-66%). Studies on alteration of HbA1C in IDA have conflicting results. Objectives: To identify and compare the effect of IDA on HbA1C levels among ...