Identification of HPV infection as the etiologic agent of virtually all cases of cervical cancer, as well as a proportion of other epithelial cancers, has led to development of three FDA-approved multivalent prophylactic HPV vaccines composed of virus-like particles (VLPs). This essay describes the research and development that led to the VLP vaccines; discusses their safety, efficacy, and shor...

The study of Borel equivalence relations under Borel reducibility has developed into an important area of descriptive set theory. The dichotomies of Silver ([19]) and Harrington-Kechris-Louveau ([5]) show that with respect to Borel reducibility, any Borel equivalence relation strictly above equality on ω is above equality on P(ω), the power set of ω, and any Borel equivalence relation strictly ...

The characteristic visual field changes of early glaucoma occur in the Bjerrum area of the visual field and are related to damage of the arcuate nerve fibre bundles (Traquair, 1944; Harrington, i964a). The susceptibility of these nerve fibre bundles at the optic nerve head to functional changes, whether reversible, relative, or absolute, is the prime characteristic feature of the glaucomatous p...

Proteolytic degradation of barley proteins is examined in green (unkilned) malt and germinating seeds from Hordeum vulgare L. cv. Harrington. Zymographic analysis of the Harrington green malt extracts using commercial preparations of barley beta-amylase incorporated as a proteolytic substrate in 2-D SDS gels shows multiple proteolytic activities. A developmental study shows that the several gre...

We reviewed the outcome of patients who had been treated operatively for symptomatic peri-acetabular metastases and present an algorithm to guide treatment. The records of 81 patients who had been treated operatively for symptomatic peri-acetabular metastases between 1987 and 2010 were identified. There were 27 men and 54 women with a mean age of 61 years (15 to 87). The diagnosis, size of lesi...

Giidel’s paper on formally undecidable propositions [3] raised the possibility that linite combinatorial theorems could be discovered which are independent of powerful axiomatic systems such as first-order Peano Arithmetic. An important advance was made by J. Paris in the late 1970’s; building on joint work with L. Kirby, he used model-theoretic techniques to investigate arithmetic incompletene...

Isaac See, MD; John R. Su, MD, PhD, MPH; Allison Lale, Emily Jane Woo, Alice Y. Guh, Tom T. Shimabukuro, MPH, MBA; Michael B. Streiff, Agam K. Rao, P. Wheeler, MSCI; Suzanne F. Beavers, Anna Durbin, Kathryn Edwards, Elaine Miller, RN, Theresa A. Harrington, MPH&TM; Adamma Mba-Jonas, Narayan Nair, Duong Nguyen, DO; Kawsar Talaat, Victor C. Urrutia, Shannon Walker, Buddy Creech, Thomas Clark, Fra...

On July 24, 2017, Chileans were hooked with the long-suffering story of Verdugo sisters in Verdades Ocultas, a Chilean telenovela anchored structural concepts classic melodrama (Fuenzalida, Corro & Mujica, 2009; Cabrujas, 2002). Its success prompted an unexpected lengthening, becoming longest history to date. Yet narrative shifts led ample changes regarding dramatic structure and seriality ...