Aim: In the most severe case of COVID-19, there is an excessive production proinflammatory cytokines, being main cause mortality and morbidity. The present study aims at assessing potential inhibitor effect six phytochemicals with anti-inflammatory activity derived from Passiflora edulis, against SARS-CoV-2 protease.
 Materials Methods: Virtual screening by molecular docking (Autodock tool...

Actinic keratoses (AK) are premalignant cutaneous lesions with limited treatment options. Here we investigate GZ21T, a novel anti-tumor agent composed of curcumin, harmine, and isovanillin, in the AK. The pro-apoptotic effects GZ21T on EGF-stimulated HaCaT cells were assessed by Annexin-V assay, mechanism was clarified western blot. Treated subjected to RNA-sequencing reverse phase protein arra...