in the present study, mitochondrial dna polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) assay was used to assess the population structure and genetic relationships among six persian sturgeon, acipenser persicus populations from south caspian sea along the iranian coast. the complete nucleotide dehydrogenase subunit 5 (nadh 5) region of mtdna amplified by pcr was di...

INTRODUCTION Uncoupling protein 2 (UCP2) reduces production of reactive oxygen species (ROS) by mitochondria. ROS overproduction is one of the major contributors to the pathogenesis of chronic diabetic complications, such as diabetic kidney disease (DKD). Thus, deleterious polymorphisms in the UCP2 gene are candidate risk factors for DKD. In this study, we investigated whether UCP2 -866G/A, Ala...

MOTIVATION Genome-wide haplotype reconstruction from sequence data, or haplotype assembly, is at the center of major challenges in molecular biology and life sciences. For complex eukaryotic organisms like humans, the genome is vast and the population samples are growing so rapidly that algorithms processing high-throughput sequencing data must scale favorably in terms of both accuracy and comp...

conclusions the widespread distribution of l. major parasites in human suggests not only t. indica was the main reservoir but also other rodents and mammalian hosts might be the reservoir hosts of zcl in the region. molecular and phylogenetic analyses confirmed the strength of haplotype variation maintaining the circulation of leishmania species in their reservoir hosts. results leishmania majo...

The problem of Haplotype Assembly is an essential step in human genome analysis. It is typically formalised as the Minimum Error Correction (MEC) problem which is NP-hard. MEC has been approached using heuristics, integer linear programming, and fixedparameter tractability (FPT), including approaches whose runtime is exponential in the length of the DNA fragments obtained by the sequencing proc...

BACKGROUND AND OBJECTIVES Major predisposing risks for the development of SLE in the nontransplant setting have been reported to include female gender, ethnicity, and genetic factors among others. In the current study, we aimed to determine whether increasing haplotype match in living donor renal transplantation would have a negative impact on the long-term rates of graft loss due to lupus neph...

INTRODUCTION Interleukin-10 (IL-10) is a multifactorial cytokine with a complex biological role in breast cancer. The aims of this study were to investigate any association between IL-10 gene promoter polymorphisms, 1082A>/G, -819T>C, and -592A>C, or haplotypes and breast cancer risk among Jordanian women and to evaluate any association between the most common haplotype with clinicopathological...

Most of the beta thalassaemia cases are heterogeneous at molecular level. The genetic variation arises due to mutation a single beta-globin gene (HBB) on chromosome 11p15.5. Eventhough, basis and natural history this disorder still not well understood clinical presentation in certain patients was always correlated with diagnosis [1].
 
 study aimed evaluate predisposing effect HBB pol...