In the field of consumer-used cosmetics for hair removal and hair growth reduction, there is a need for improved quantitative methods to enable the evaluation of efficacy and claim support. Optimized study designs and investigated endpoints are lacking to compare the efficacy of standard methods, like shaving or plucking, with new methods and products, such as depilating instruments or hair-gro...

BACKGROUND To pical minoxidil solution 2% stimulates new hair growth and helps stop the loss of hair in men with androgenetic alopecia and women with female pattern hair loss. Results can be variable, and historic experience suggests that higher concentrations of topical minoxidil may enhance efficacy. OBJECTIVE The purpose of this 48-week, double-blind, placebo-controlled, randomized, multic...

The influence of melanin on the binding of xenobiotics in hair will impact the interpretation of drug concentrations determined by hair testing. The purpose of this study was to determine if codeine, as a model compound of abused drugs, would be incorporated into black, brown, blond, or red hair as a function of melanin concentration. Such data would assist in the interpretation of codeine conc...

Hair dyes and their ingredients have moderate to low acute toxicity. Human poisoning accidents are rare and have only been reported following oral ingestion. Contact sensitisation to hair dyes has been a safety issue, mainly as a consequence of unprotected professional exposure. Although the use of hair dyes has dramatically increased in industrialised countries during the last decades, the pre...

Using mouse gene expression microarray analysis, we obtained dynamic expression profiles of the whole genome in a depilation-induced hair growth mouse model. S100A3 expression increased during the anagen phase and returned to normal during the telogen phase. The effects of S100A3 blockade on the hair growth cycle were examined in mice after subcutaneous injection of an anti-mouse S100A3 antibod...

The interaction and the function of some amino acids in hair care applications are discussed. When amino acids are applied to hair in the form of simple aqueous solution, uptake of the amino acids is mainly controlled by ionic equilibrium. When amino acids were incorporated in a hair conditioner, the result was quite different, suggesting the importance of interaction between the amino acids an...

Hair differentiates from follicle stem cells through progenitor cells in the matrix. In contrast to stem cells in the bulge, the identities of the progenitors and the mechanisms by which they regulate hair shaft components are poorly understood. Hair is also pigmented by melanocytes in the follicle. However, the niche that regulates follicular melanocytes is not well characterized. Here, we rep...

background: segmental vitiligo is a small subset albeit persistent form of focal vitiligo with dermatomal distribution and resistant to medical therapy. in recent years, surgical therapy as hair follicle autograft transplantation has been a hot topic in management of segmental vitiligo. in this study, we evaluated the efficacy of this method in segmental vitiligo lesions. methods: the study rec...

in this study, generation of the transient evoked ooacoustic emissions in human ear has been simulated using a new electroacoustic model. the method of state variables was adopted to calculate the auditory model, and numerical integration methods have been used to solve differential equations in matlab. simulation results have been compared with the real data. in this study, latency curves, fre...

hallaj, facing different circumstances, is considered as a mysterious experience in the history and when he resisted the government, he met his dark fate and condemned to death.  the age in which hallaj lived was the real renaissance in islamic thought. massignon resembles this age with that of the fifteenth century in the west. but hallaj was economically belonged to poor rank, and scientifica...