Systolic blood pressure variability is an independent risk factor for mortality and cardiovascular events. Standard measures of blood pressure predict outcome poorly in haemodialysis patients. We investigated whether systolic blood pressure variability was associated with mortality in incident haemodialysis patients. We performed a longitudinal observational study of patients commencing haemodi...

OBJECTIVE To assess if malnutrition influences the response to the hepatitis B virus vaccine in haemodialysis patients and whether this correlates with morbidity and mortality in these patients. DESIGN A 4-year prospective open study. SETTING Haemodialysis unit of a 434-bed University Hospital. PATIENTS Sixty-four patients with end-stage chronic renal failure on maintenance haemodialysis....

BACKGROUND Ferumoxytol is approved for the treatment of iron-deficiency anaemia (IDA) in adult patients with chronic kidney disease (CKD). Ferumoxytol has recently been investigated for use in all-cause IDA. This analysis was employed to bridge ferumoxytol pharmacokinetics (PK) across populations of healthy subjects and patients with CKD on haemodialysis, and to then make informed inferences re...

BACKGROUND Doppler ultrasound methods were used during haemodialysis sessions for the detection of microemboli and determination of their origin. METHODS A 2-MHz ultrasound probe (Multidop X(4) DWL((TM))) was used to assess the number of microembolic signals (MES) in the subclavian vein downstream from the arteriovenous fistula before the dialysis session and over two periods of 15 min at the...

BACKGROUND A single bolus dose of LMW heparin at the start of haemodialysis effectively prevents clot formation in the dialyser and bubble trap. However, there are few studies on the appropriate dosage of LMW heparins in haemodialysis. Therefore we examined the relationship between the anticoagulant effect of dalteparin and clinical clotting during haemodialysis. METHODS We performed an open,...

BACKGROUND Dyslipidaemia is a major risk factor of cardiovascular disease in patients on maintenance haemodialysis. Both increased and decreased levels of cholesterol are associated with increased cardiovascular mortality in haemodialysis patients. OBJECTIVE To assess the lipid dysfunction among patients on maintenance haemodialysis in a nephrology unit at Rawalpindi as compared with healthy ...

BACKGROUND Vascular calcification has detrimental consequences on chronic kidney disease (CKD) patients, yet its pathogenesis is not fully understood. Fibroblast growth factor-23 (FGF-23) is involved in the regulation of mineral metabolism which may in turn affect vascular calcification. Data on the relationship between FGF-23 and peripheral vascular calcification, using conventional radiograph...

Oxidative stress defines an imbalance between formation of reactive oxygen species (ROS) and antioxidative defence mechanisms. In view of the profound biological effects of ROS, in recent years numerous clinical and experimental studies focused on detection of signs of oxidative stress in renal patients. There is good evidence indicating that uraemia in general is associated with enhanced oxida...

Background and Purpose: Difficulty in acceptance of illness adherence to fluid control are common patients receiving haemodialysis treatment, they associated with higher morbidity mortality. This study aims identify the effects training based on Roy Adaptation Model, which is given treatment illness, control. 
 Methods: The was designed as a nonrandomised interventional study. conducted 81...

The importance of extracellular volume control and avoidance overload has been well documented in relation to the management patients with chronic haemodialysis. Chronic results poorly controlled hypertension, increased cardiovascular events, all-cause mortality. Traditional methods dry weight assessment have relied on clinical guide status. challenge achieving balance between weights preventin...