Recurrent Spontaneous Abortion (RSA), Habitual Abortion or Habitual Miscarriage is the loss of 3 or more consecutive pregnancies before the 24 week of gestation. RSA occurs chiefly due to either a problem with the pregnancy or when there is a problem in the environment where it implants and further development occurs. 10-15 % of women with recurrent early pregnancy loss have congenital uterine ...

An increased frequency of mitoses with centromere separation affecting all chromosomes was found in lymphocyte cultures of couples with recurrent spontaneous abortions. This anomaly was recorded in six individuals out of seventy couples (one hundred and forty individuals) with recurrent miscarriages. The abnormal behaviour of centromeres may predispose the individual to cell division errors, th...

During the secretory phase of the menstrual cycle, the composition of extracellular matrix (ECM) in endometrium changes to favour implantation. In the present study, we have analysed whether some cases of unexplained infertility and recurrent abortions could be explained by abnormal production or turnover of endometrial ECM. Comparison of mRNA levels of a panel of collagens, matrix metalloprote...

OBJECTIVES To analyze the social factors influencing unmarried pregnancies in urban population. METHODOLOGY Observational study was conducted at the Institute of Obstetrics and Gynaecology, Chennai, from January 2006 to December 2010. Convenience sampling technique was used, and 115 subjects were interviewed using structured questionnaire. RESULTS 15.6 % of the subjects were <16 years of ag...

In the present study, we analyzed the proliferation and apoptosis of trophoblasts and human decidual cells in patients with recurrent spontaneous abortion and the related cellular pathway mechanism. Thirty-four patients with recurrent abortion and 30 healthy pregnant women undergoing planned artificial abortion were selected. The trophoblast and decidual cells were collected by negative pressur...

BACKGROUND Polymorphisms which are presented below may be the cause of inherited thrombophilia and may result in pregnancy loss. The hypothesis is based on a number of cardiology studies which have confirmed the involvement of these polymorphisms in thrombotic incidents. OBJECTIVES To evaluate the role of polymorphisms of factor VII gene (Arg353Gln, -122T > C) and PAI-1 gene (-675 4G/5G) in t...

OBJECTIVE To analyze the chromosomal abnormalities in couples with history of recurrent abortions. DESIGN Retrospective study. SETTING Cytogenetic section, Department of Pathology at the Aga Khan University Hospital, Karachi, Pakistan. PATIENTS Three hundred couples with history of recurrent abortions. MAIN OUTCOME MEASURE Structural chromosomal abnormalities in carrier couples. RESUL...

Background: Pregnancy loss is a common phenomenon. Most of the pregnancy losses which happen in the first and second trimesters are caused by chromosomal abnormalities. Repeated pregnancy loss is an extremely stressful condition for both the partners and physicians because it is difficult to find a reason behind it. Materials and Methods: Cytogenetic analysis was performed according to standard...