In this study, a total of 380 raw meat samples (pork, beef, and chicken) were collected randomly from traditional markets in Ho Chi Minh City (Vietnam). Salmonella strains were isolated by cultivation methods according to ISO 6579-1:2017, subsequently confirmed by PCR method (TCVN 8342:2010). These used test antibiotic susceptibility in six kinds antibiotics ...

Heteroaryl isothiazolones (HITZs) are antibacterial agents that display excellent in vitro activity against Staphylococcus aureus. We recently identified a series of these compounds that show potent bactericidal activities against methicillin-resistant Staphylococcus aureus (MRSA). We report here the results of in vitro resistance studies that reveal potential underlying mechanisms of action. H...

Aerococcus urinae and Aerococcus sanguinicola are emerging Gram-positive pathogens responsible for urinary tract infections, especially in elderly patients (2). Although they seem to be intrinsically susceptible to fluoroquinolones (3, 8, 10), acquired fluoroquinolone resistance has not been yet reported. Resistance to fluoroquinolones in Gram-positive bacteria is mainly due to point mutations ...

Nontyphoidal Salmonella enterica strains with a nonclassical quinolone resistance phenotype were isolated from patients returning from Thailand or Malaysia to Finland. A total of 10 isolates of seven serovars were studied in detail, all of which had reduced susceptibility (MIC > or = 0.125 microg/ml) to ciprofloxacin but were either susceptible or showed only low-level resistance (MIC < or = 32...

We evaluated the in vitro activity of delafloxacin against a panel of 117 Neisseria gonorrhoeae strains, including 110 clinical isolates collected from 2012 to 2015 and seven reference strains, compared with the activities of seven antimicrobials currently or previously recommended for treatment of gonorrhea. We examined the potential for delafloxacin to select for resistant mutants in ciproflo...

Escherichia coli isolates from diseased piglets (n = 89) and chickens (n = 71) in China were characterized for O serogroups, virulence genes, antimicrobial susceptibility, class 1 integrons, and mechanisms of fluoroquinolone resistance. O78 was the most common serogroup identified (63%) among the chicken E. coli isolates. Most isolates were PCR positive for the increased serum survival gene (is...

Objectives: Quinolone resistance in Escherichia coli occurs mainly as a result of mutations the quinolone-resistance-determining regions gyrA and parC, which encode drugs’ primary targets. Mutational alterations affecting drug permeability or efflux well plasmid-based mechanisms can also contribute to resistance, albeit lesser extent. Simplifying generalizing complex evolutionary trajectories, ...

Development of fluoroquinolone resistance can involve several mechanisms that include chromosomal mutations in genes ( gyrAB and parCE ) encoding the target bacterial topoisomerase enzymes, increased expression AcrAB-TolC efflux system, acquisition transmissible quinolone-resistance genes. In this study, 176 Salmonella isolates from animals with a broad range ciprofloxacin MICs were collected t...