Skin disease may be the most common reason that owners take their guinea pigs to a veterinarian. In addition, skin diseases are very common in laboratory colonies and may interfere with the quality and conditions of research. Most skin conditions in guinea pigs are due to infectious diseases, of which the most frequent cause is parasites. This article organizes skin diseases of guinea pigs base...

UNLABELLED Influenza D virus (FLUDV) is a novel influenza virus that infects cattle and swine. The goal of this study was to investigate the replication and transmission of bovine FLUDV in guinea pigs. Following direct intranasal inoculation of animals, the virus was detected in nasal washes of infected animals during the first 7 days postinfection. High viral titers were obtained from nasal tu...

Various investigators have reported changes in the concentration of the free amino acids in blood plasma and tissues of guinea-pigs in acute vitamin C deficiency. Christensen & Lynch (1948) found in guinea-pigs deficient in ascorbic acid a large decrease in the glycine and glutamine contents of skeletal muscle and in the glutamine content of the liver. Levels of amino acids other than glycine a...

Bolus injection of lethal or sublethal doses of endotoxin or lipopolysaccharide (LPS) results in the rapid and transient rise in tumor necrosis factor (TNF) levels in serum in mammals. TNF levels peak between 1 and 2 h after LPS injection in mice and guinea pigs and approach basal levels by 6 h. Although the kinetics of TNF in serum appear similar between these two species, guinea pigs respond ...

The experiments of Sealock et al. (l-3) and of Levine et al. (4) have given reasons for believing that one of the functions of ascorbic acid in the animal body is to facilitate the metabolism of L-tyrosine and L-phenylalanine. Sealock and Silberstein (2) showed that the administration of tyrosine orally to scorbutic guinea pigs resulted in the excretion of metabolites containing the benzene rin...

Previous research has suggested that dietary protein deficiency alters resistance to experimental pulmonary tuberculosis, in part, by affecting the distribution and trafficking of antigen-reactive T cells. In this study, guinea pigs were maintained on either a protein-deficient (10% ovalbumin) or control (30% ovalbumin) diet and infected 4 to 6 weeks later with a low dose of virulent Mycobacter...

We recently discovered that regular alcohol consumption reduces ischemia-reperfusion injury to the same degree as ischemic preconditioning in guinea pig hearts. Ischemic preconditioning, like this cardioprotective effect of alcohol, is mediated by adenosine signaling in guinea pigs. In rats, ischemic preconditioning may be mediated predominantly by α1-adrenergic signaling. To be certain that th...

BACKGROUND The influenza viruses circulating in animals sporadically transmit to humans and pose pandemic threats. Animal models to evaluate the potential public health risk potential of these viruses are needed. METHODOLOGY/PRINCIPAL FINDINGS We investigated the guinea pig as a mammalian model for the study of the replication and transmission characteristics of selected swine H1N1, H1N2, H3N...

The guinea-pig was previously reported as being sensitive to a niacin-deficient (ND), high-protein diet, suggesting that it is a suitable model for the low tryptophan to NAD+ conversion observed in human subjects. However, these studies were based on growth rates and mortality. The objective of the present study was to determine whether guinea-pigs are suitable for ND studies based on measureme...

Production rates of cortisol, 2a-hydroxycortisol, and 6/3hydroxycortisol were determined (by isotope dilution technics) in individual adult Strain 2 guinea pigs following transplantation of the guinea pig lymphoblastic leukemia I^C/NB. There was a statistically significant (P < 0.01, 0.02, and 0.01) 2.0-, 1.4-, and 1.9-fold higher production of cortisol, 2a-hydroxycortisol, and 6/3-hydroxycorti...