PURPOSE To establish a new mouse model for wound healing studies on hemophilia A. METHODS Total 54 male mice with different genotypes including wild-type nude mice, heterozygous mice (FVIII-/-/Nu) and FVIII deficient mice (FVIII-/-) were generated and verified by PCR. Mice were subjected to wound healing research by making a 5 mm-thickness wound on mice skin and applying recombinant human epi...

Mthough a vasodilator drug might favorably alter hemoynamics in resting, supine patients with heart failure, It must be determined If the drug has any unfavorable as well as favorable effects under extremes of real life sfress situations normally encountered by ambulatory patients, especially upright exercise. An adverse response might occur with the addition of pharmacologic vasodilatlon to th...

OBJECTIVE Clinical efficacy and safety of Polyphenon(R) E, a defined green tea extract, in external genital warts. DESIGN Randomized, double-blind, placebo-controlled study for up to 12 weeks with a 12-week treatment-free follow-up. SETTING Twenty-eight hospitals and practices in Germany and Russia. PATIENTS Two hundred forty-two outpatients (125 men, 117 women) with 2 to 30 warts (total ...

Topical acyclovir (ACV) in polyethylene glycol (PEG) ointment has been disappointing in the treatment of recurrent herpes simplex virus infections in immunocompetent patients. To investigate the possible role of poor drug delivery from this formulation, we studied the penetration of ACV through excised human skin from three vehicles; PEG ointment, modified aqueous cream, and dimethyl sulfoxide....

Background. Facial angiofibromas affect most patients with tuberous sclerosis complex. They tend to progress, can cause recurrent bleeding and facial disfigurement, and have significant psychological effects. We reviewed the effectiveness and safety of topical sirolimus ointment 0.1%. We also assessed the effect of treatment on quality of life. Methods. We report our experience in using sirolim...

INTRODUCTION The standard postsurgical treatment of wounds after dermatologic procedures is currently limited. Topical corticosteroids have been used successfully in postoperative management of ophthalmologic surgeries that involve the skin of the eyelid. In particular, tobramycin 0.3%/dexamethasone 0.1% ophthalmic ointment is considered the "gold standard" of steroid-antibiotic fixed combinati...

BACKGROUND Burn is the most devastating condition in emergency medicine leading to chronic disabilities. This study aimed to compare the effect of Lithospermum officinale, silver sulfadiazine and alpha ointments on healing of burn wounds in rat. METHODS Ninety-five rats were divided into 5 groups. Group 1 just underwent burn injury, and groups 2-5 received alpha ointment, silver sulfadiazine ...

OBJECTIVE To compare the parasitological and clinical efficacy of four weeks versus two weeks of treatment with aminosidine (paromomycin) ointment in patients with cutaneous leishmaniasis caused by Leishmania major in the Islamic Republic of Iran. METHODS Double-blind, randomized trial of four weeks of aminosidine ointment (n = 108) vs two weeks of aminosidine ointment and two weeks of placeb...

Background: Woodfordia fruiticosa Kurz. of Lythraceae is a shrub whose blooms are called Dhataki Kusuma. The fresh flower W. fruticosa controls bleeding in emergency cuts, whereas the dried powder heals wounds faster. Indian tribes utilise it to cure wounds. No scientific evidence supported using treat wounds, hence present study assessed plant's wound healing ability. Aim: To find out efficacy...