The need for an effective TB (tuberculosis) vaccine remains acute, with tuberculosis still one of the major killers worldwide and 3 million new infections annually. We report here on the immune responses elicited by HspCs (heat-shock protein-peptide complexes) isolated from BCG (Bacille Calmette-Guérin) vaccine. These HspCs elicit both the appropriate cellular and protective immune responses re...

In vitro T-cell based interferony (IFNy) release assays (IGRAs), the QuantiFERON-TB Gold In-Tube test (QFN-GIT) (Cellestis Limited, Carnegie, Victoria, Australia) and the T-SPOT. TB test (T-Spot) (Oxford Immunotec Limited, Abingdon, United Kingdom), are marketed as a substitute for the tuberculin skin test (TST). The specificity of these immunoassays has been optimised by using Mycobacterium tu...

Bacillus Calmette-Guérin (BCG) is a live attenuated strain of Mycobacterium bovis that has been widely used for the treatment of superficial transitional cell carcinoma of the bladder. We describe a rare case of supra-renal mycotic aortic aneurysm secondary to BCG instillation in a 75-year-old male. Patients presenting with systemic symptoms post-instillation, possibly with an aneurysm, should ...

We evaluated local reactions at 1, 2, and 4 months of age to bacille Calmette-Guérin vaccine given at birth to 1058 infants who were exposed to human immunodeficiency virus (HIV). No scar was discernible in 12 (12.4%) of 97 HIV-infected infants and 20 (2.1%) of 961 uninfected infants (relative risk, 5.9; 95% confidence interval, 3.0-11.8). This difference may reflect poorer immunogenicity in HI...

We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 µm resolution, a 750 µm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detec...

2014 Bacillus Calmette-Guérin (BCG) is a vaccine derived from attenuated strains of Mycobacterium bovis. Mycobacterium bovis BCG-based therapy is considered an effective alternative for bladder carcinoma in situ when exclusive transurethral resection is inadequate. Among the complications associated with therapy, there are few reports in the literature on reactive arthritis. We report the case ...

Intravesical instillation of Bacillus Calmette-Guérin (BCG) is the treatment of choice for superficial bladder carcinoma. We report a case of disseminated BCG infection in an early stage bladder cancer patient that initially presented with hepatitis followed by pneumonitis and sepsis. A complete clinical response was achieved in 14 days with anti-mycobacterial therapy and prednisolone. Dissemin...

(KIR) gene in children with Bacille Calmette-Guérin lymphadenitis Hyo Jin Kwon, MD; Seong Joon Kim, MD; Jong-Hyun Kim, MD, PhD; HeeBaeg Choi; Tai-Gyu Kim, MD, PhD; Dae Kyun Koh, MD, PhD; Jin Han Kang, MD, PhD; Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Microbiology, College of Medicine, The Catholic University of Korea, Seo...

In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient wi...

D. Sugny, A. Keller, O. Atabek, D. Daems, C. M. Dion, S. Guérin, and H. R. Jauslin 1 Laboratoire de Physique de l’Université de Bourgogne, UMR CNRS 5027, BP 47870, 21078 Dijon, France 2 Laboratoire de Photophysique Moléculaire du CNRS, Université Paris-Sud, Bât. 210 Campus d’Orsay, 91405 Orsay Cedex, France 3 Center for Nonlinear Phenomena and Complex Systems, Université Libre de Bruxelles, 105...