In patients with severe, treatment-refractory Gilles de la Tourette syndrome (GTS), deep brain stimulation (DBS) of various targets has been increasingly explored over the past 15 years. The multiplicity of surgical targets is intriguing and may be partly due to the complexity of GTS, specifically the various and frequent associated psychiatric comorbidities in this disorder. Thus, the target c...

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background: gts, ptsm and atsm are bis-thiosemicarbazone ligands used in the preparation of copper radiopharmaceuticals. chemical structure of these materials indicates that they should have radio-protective effects. objective: to study the radio-protective effects of gts, ptsm and atsm. methods: this study has focused on radio-protective effects of these compounds at different doses (20, 40 an...

The CD14-dependent and -independent dendritic cell (DC) pathways are instituted simultaneously when CD341 progenitor cells are treated with granulocyte-macrophage colonystimulating factor (GM-CSF)/tumor necrosis factor (TNF) 6 stem cell factor (SCF) (GTS). If TNF activity is neutralized within 48 hours of cytokine exposure, DC development is halted and myelogranulocytic hematopoiesis takes plac...

Tuberomammillary histamine neurons (TM) of the posterior hypothalamus exclusively express alpha-bungarotoxin (alphaBgt) sensitive nicotinic receptors, providing a unique model system for studying physiological properties of native alpha7-like receptors. Here the properties of alphaBgt-sensitive receptors were investigated using the patch-clamp technique and rapid application of acetylcholine (A...

One approach to treatment of negative cognitive effects associated with Alzheimer's disease and schizophrenia may involve activation of neuronal α7 nicotinic acetylcholine receptors (nAChRs). We used the α7-selective partial agonist 3-(4-hydroxy, 2-methoxy-benzylidene)anabaseine (4OHGTS-21), the α7 modulator 5-hydroxyindole (5-HI), and recombinant adeno-associated virus (rAAV)–mediated α7 gene ...

Glioblastoma multiforme (GBM) is the most common malignant brain tumour in adults. The poor prognosis and short median overall survival of patients with GBM associated resistance to therapy after surgical adjuvant treatment. expression various acetylcholine receptors (AChR) has been widely reported. present study aimed investigate cholinergic system‑related genes primary explore antiproliferati...

We develop a new efficient simulation scheme for sampling two families of tilted stable distributions: exponential (ETS) and gamma (GTS) distributions. Our is based on two-dimensional single rejection. For the ETS family, its complexity uniformly bounded over all ranges parameters. This algorithm outperforms existing schemes. In particular, it more than well-known double rejection scheme, which...

Energy efficiency is one of the major challenges in IEEE 802.15.4 based Internet Things (IoT). In Medium Access Control (MAC) layer standard, Guaranteed Time Slot (GTS) are allocated to IoT devices for data transmission. However, GTS allocation does not consider residual energy resulting reduced life cycle these devices. this paper, we propose an efficient MAC protocol RF harvesting The propose...