abstract introduction major ß thalassemia represents a group of recessively inherited hemoglobin disorder, which is characterized by reduced synthesis of globins chains. frequent blood transfusions can lead to iron overload, which may result in several endocrine complication especially in the absence of adequate chelating therapy. the objective of this study were to determine the prevalence of ...

TGF-ß is a multifunctional cytokine that is involved in cell proliferation, differentiation and function. We previously reported an essential role of the TGF-ß -Smad2/3 pathways in RANKL-induced osteoclastogenesis. Using chromatin immunoprecipitation followed by sequencing, we comprehensively identified Smad2/3 target genes in bone marrow macrophages. These genes were enriched in the gene popul...

Here we investigate how ß-adrenergic stimulation of the heart alters regulation of ryanodine receptors (RyRs) by intracellular Ca(2+) and Mg(2+) and the role of these changes in SR Ca(2+) release. RyRs were isolated from rat hearts, perfused in a Langendorff apparatus for 5 min and subject to 1 min perfusion with 1 µM isoproterenol or without (control) and snap frozen in liquid N2 to capture th...

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) functions both in regulation of insulin secretion and neurotransmitter release through common downstream mediators. Therefore, we hypothesized that pancreatic ß-cells acquire and store the information contained in calcium pulses as a form of "metabolic memory", just as neurons store cognitive information. To test this hypothesis, we develop...

Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these processes are also an integral part of amelogenesis. In order to delineate a precise role of TGF-ß signaling during amelogenesis, we developed a transgenic mouse line that harb...

The theorem about primitive divisors in algebraic number fields is generalized in the following manner. Let A, B be algebraic integers, (A, B) = 1 , AB ^ 0, A/B not a root of unity, and Çk a primitive root of unity of order k . For all sufficiently large n , the number A" C,kB" has a prime ideal factor that does not divide Am £,'kBm for arbitrary m < n and j < k . The analogue of Zsigmondy's th...

ß-Cyclodextrin (ß-CD) solubilizes stickies from deinked pulp, commercial adhesive formulations, or magazine inserts, which demonstrates its potential as a washing aid. A new test to simulate coater scratches is described; it involves scraping the test paper sample across the surface of a thin layer chromatography plate and measuring the degree of scratching on the plate. Scratching was signific...

Due to the asymmetry introduced by the hypothesis (2), the above theorem leaves open the case where ß >ct. Actually, the entire theorem as it stands holds without hypothesis (3). This results from the fact that Erdös' proof of the theorem given in [l ] uses only the condition a>ß/2. In the contrary case, 2a=/3, if we let ai be any fixed integer of A, the set {ö+cti}, b^B, has asymptotic density...

Objective: Several studies have shown that the adult pancreas possesses a limited potential for ß– cell regeneration upon tissue injury. One of the difficulties in studying ß-cell regeneration has been the lack of a robust, synchronized animal model system that would allow controlled regulation of ß−cell loss and subsequent proliferation in adult pancreas. Research Design and Methods: Here we p...

für die resultierende mittlere Geschwindigkeit eines Teilchens nach einem Stoß: t>red = v c p . Aus den Gesetzen des elastischen Stoßes für Kugeln der Massen m0, mx ergibt sich für die Geschwindigkeit von 77i0 nach dem Stoß mit ß = ( (m x m0 ) / (m, + m 0 ) ) 2, e=(l/ß-l) (d/R0)2 : v=v0(ßey*(( 1 + 1/fi) — cos2 ft)1'*; (A.6) cos #m i n = (1 (R0/d)2 (ß (vmJv 0)2)/ (ß-1) cos # m a x = (1 (R0/d)2)1...