AIM The aim of this study is to determine the relationship between TRAb and different diseases. The highest percentage of increased TRAb levels can be found at patients with Graves'™ diseases. MATERIAL AND METHODS Study was performed in 70 patients, grouped in three gr oups, and 14 persons who based on the clinical status and the levels of thyroid hormones do not ha ve any thyroid disease. Th...

Cytotoxic anti-thyroid microsomal autoantibodies are highly prevalent in sera of patients with Graves' disease, but in Graves' disease thyroid tissues rarely show destructive changes. We postulated that this might be due to membrane-associated complement regulatory proteins which protect target cells from injury by complement activation. We, therefore, investigated the expression of membrane at...

Graves' disease is an autoimmune disorder of the thyroid gland with characteristic peripheral manifestations. The most common clinical findings include ophthalmopathy in 30% of patients, dermopathy (pretibial myxedema) in 4% of patients, and thyroid acropachy in 1% of patients. The triad of exophthalmos, pretibial myxedema, and acropachy occurs in less than 1% of patients. We present a case of ...

Graves' disease includes thyrotoxicosis, goiter, exophthalmos, and pretibial myxedema when fully expressed, but can occur with one or more of these features. Graves' disease is a disease of "autoimmunity", but the final cause of autoimmunity remains unclear. A strong hereditary tendency is present. Inheritance of HLA antigens DR3, DQ 2, and DQA1*0501 predispose to Graves' disease. The abnormal ...

Surgical Treatment. -By Israel Bram, m.d. C. V. Mosby Company, St. Louis, 1920. Thk author should entertain no fear that his book may not be tolerated: it rather requires a welcome. The whole subject of Graves' disease is carefully reviewed: no new theories of its pathogenesis are advanced, but the author inclines to the view that the hyperthyroidism of the disease is itself an incidental produ...

BACKGROUND Thyrotoxicosis is a cause of secondary osteoporosis. High concentrations of triiodotironine (T3) in Graves' disease stimulate bone turnover, but it is unclear if euthyroidism will always normalize bone metabolism. Thyrotropin (TSH) is known to affect directly the bone metabolism through the TSH receptor and TSH receptor antibodies (TRAb) may have an important role in bone turn-over.T...