Liver injury was induced in female rats using tamoxifen (TAM). Grape seeds (Vitis vinifera) extract (GSE), black seed (Nigella sativa) extract (NSE), curcumin (CUR) or silymarin (SYL) were orally administered to TAM-intoxicated rats. Liver histopathology of TAM-intoxicated:rats showed pathological changes. TAM-intoxication elicited declines in liver antioxidant enzymes levels (glutathione perox...

Chronic inflammatory bowel disease is characterised by an up-regulation of the synthesis and release of a variety of pro-inflammatory mediators leading to excessive tissue injury. Flavonoids are able to inhibit enzymes and/or due to their antioxidant properties regulate the immune response. The goal of the present study was to evaluate the mechanisms of action of phenolic compounds present in g...

To elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE), we explore whether GSPE regulates the inflammatory response of TNBS-induced colitis in rats at the levels of NF-κB signal transduction pathway. Rats were intragastrically administered of different doses of GSPE (100, 200 and 400 mg·kg-1) per day for seven days after ulcerative...

This study aimed to optimize the extraction solvents for Bordo grape (Vitis labrusca) seeds by response surface methodology regarding antioxidant activity (AA) and trans-resveratrol content. Fatty acids (FA) AA of oil obtained pressing cold method were also determined. The optimization was determined statistical simplex-centroid mixing scheme, enabling analysis effects (water, ethanol acetone) ...

In this paper we describe the current status of the GRAPE-6 project to develop a special-purpose computer with a peak speed exceeding 100 T ops for the simulation of astrophysical N -body problems. One of the main targets of the GRAPE-6 project is the simulation of dense stellar systems. In this paper, therefore, we overview the basic algorithms we use for the simulation of dense stellar system...

Abstract The aim of this work is to evaluate the role Grape Seed extracts (GSE) from three grape cultivars (Ahmer, Halawani, and Kamali) grown in Iraq as well pomace on lipid profile diabetic mice. Fifty adult female mice were divided into five groups. Negative control (untreatment), positive (treated) diabetic, treated with GSE. After six weeks; serum liver tissue homogenate parameters evaluat...