Abstract Background and aims Cytotoxic CD8+ T cells mediate myocardial damage in patients with virus induced myocarditis, plaque erosion during acute coronary syndrome, promote adverse post-ischemic cardiac remodeling. There is emerging evidence to support a link between inflammation atrial fibrillation (AF). Protease-activated receptor 1 (PAR1) the thrombin expressed on platelets, but it also ...