We investigated the effects of 2-methyl-5-HT and 1-phenylbiguanide on isolated and perfused rabbit common carotid arteries by a cannula insertion method. 1-Phenylbiguanide produced neither vasoconstriction nor dilation. On the other hand, 2-methyl-5-HT produced only a vasoconstriction, and the dose-response curve was shifted to the right in parallel by treatment with either ketanserin or bunazo...

Approximately 2% of bladder malignancies are metastatic. The lung cancer makes metastasis sporadically to the bladder. A-69-year-old female patient presented with a history of pain in kidneys, vomiting and hematuria. Cystoscopic examination of the patient revealed small bladder capacity and solitary lesions in the bladder wall. Thoracic computed tomography scan identified multiple solid masses ...

Postoperative nausea and vomiting (PONV) is the second most common complaint in postoperative period especially high risk surgeries like laparoscopic cholelithiasis. Many pharmacological strategies has been used for its prevention as PONV may cause adverse effects. Drugs granisetron dexamethasone alone combination prophylaxis of PONV. We observed adequacy safety these drugs by injecting (40mcg/...

Background Intrathecal morphine (ITM) has proven to be excellent in reducing postoperative pain. However, its use is associated with the occurrence of nausea and vomiting (PONV). In this study, we wish compare efficacy between combination therapy granisetron dexamethasone versus alone on (PONV) parturients undergoing elective Caesarean delivery.Method This a prospective double-blinded, randomis...

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...