Adenocarcinoma as a cause of acute appendicitis is unusual, occurring in approximately 1.0% of all cases of appendicitis. Nevertheless, management of appendiceal adenocarcinoma as a routine appendicitis may have an adverse outcome for the patient. Iatrogenically, a contained malignant process may be converted into a disseminated disease that will have a lethal outcome. Staging of appendiceal ad...

objective: micrornas (mirnas) are a new class of non-coding rnas involved in regulating various biological processes including proliferation, differentiation, and apoptosis, among others. alterations in mirna expression are reported in several human cancers, which suggests their potential roles in tumor initiation and progression. members of the mir-302 cluster are highly expressed in embryonic...

Purpose: Esophageal adenocarcinoma is a highly aggressive malignancy that frequently develops from Barrett's esophagus, a premalignant pathologic change occurring in the lower end of the esophagus. Identifying Barrett's esophagus patients at high risk of malignant transformation is essential to the prevention of esophageal adenocarcinoma. Although microRNA (miRNA) expression signatures have bee...

Abstract Background A metaplasia-dysplasia–carcinoma sequence is the most plausible carcinogenic pathway for gallbladder cancer. Although incidence of carcinoma increasing, little known about its precancerous lesions. The aim this study was to determine temporal changes in prevalence low-grade dysplasia (LGD), high-grade (HGD) and adenocarcinoma associated risk factors. Methods We retrospective...

The 2015 World Health Organization (WHO) lung adenocarcinoma classification divides tumours into categories of indolent pre-invasive, minimally invasive and predominantly lepidic and, by examining predominant patterns of invasion, allows for further stratification into intermediate and high-grade tumours. The impact of the 2015 classification on prognosis was reviewed by a PubMed search for sea...

BACKGROUND The efficacy of endoscopic biopsy surveillance of Barrett's oesophagus in reducing mortality from oesophageal cancer has not been confirmed. AIMS To investigate the impact of endoscopic biopsy surveillance on pathological stage and clinical outcome of Barrett's carcinoma. METHODS A clinicopathological comparison was made between patients who initially presented with oesophageal a...

Polymorphous low‐grade adenocarcinoma (PLGA) is difficult to diagnose due to its indolent clinical presentation and due to its morphological diversity that includes several microscopic patterns. Distinguishing it from high‐grade tumors of salivary gland is important, as the management and prognosis of this tumor differ. We report a considerably rare case of PLGA in retromolar area highlighting ...

Urocortin (UCN) is a 40-amino acid neuropeptide sharing 45% sequence homology with corticotropin-releasing factor (CRF). The human endometrium expresses both UCN and CRF, and CRF/UCN receptors type-1 (CRF-R1) and -2 (CRF-R2). CRF-R1 activation inhibits cell growth and proliferation of a tumor cell line derived from the human endometrium, and the UCN signaling pathway has been implicated in tumo...

Interleukin-11 (IL-11) up-regulates the proliferative and invasive capacity of many cancers. Coexpression of glycoprotein 130 (GP130) and IL-11 receptor alpha (IL-11Ralpha) is necessary for high-affinity binding of IL-11 to IL-11Ralpha. This study investigated the expression of IL-11 and role of prostaglandin F(2alpha)-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 exp...

Background: Cervical cancer has an increased rate of morbidity and mortality among women most commonly in terms cervical adenocarcinoma. Histopathology been considered as the foundation for diagnosing tissue changes associated with cancer. However, there are controversies identifying their prognostic value. Methods: It is a retrospective study which 100 participants suffering from adenocarcinom...