Abnormal choline phospholipid metabolism is a hallmark of cancer. The magnetic resonance spectroscopy (MRS) detected total choline (tCho) signal can serve as an early noninvasive imaging biomarker of chemotherapy response in breast cancer. We have quantified the individual components of the tCho signal, glycerophosphocholine (GPC), phosphocholine (PC) and free choline (Cho), before and after tr...

The Generalized Predictive Controller (GPC) [1], [2] belongs to the general class of predictive controllers. The authors have proposed an alternative (although equivalent) formulation for the GPC in state space [7]. This formulation is based on a robust observer [5], and the poles selection is closely related to the controller robustness. An important feature of predictive controllers consists ...

Wheat (Triticum aestivum L.) is one of the most important agricultural crops in China. In addition to the yield, the grain quality of wheat is central to the well-being of humans. Because of its high grain protein content (GPC), wheat is extensively applied in many foods and industrial uses. Currently, increasing grain quality is becoming a widely discussed topic in crop sciences. Wheat quality...

Acyl-CoA:2-acyl-sn-glycero-3-phosphocholine (GPC) acyltransferase is required for the maintenance of the asymmetric distribution of saturated fatty acids at the C-1 position of phosphatidylcholine; however, this activity has been reported to be absent in cardiac tissue. In the present study a very active acyl-CoA:2-acyl-GPC activity was detected and characterized in guinea-pig heart microsomes ...

Graph Proximity Cleansing (GPC) is a string clustering algorithm that automatically detects cluster borders and has been successfully used for string cleansing. For each potential cluster a so-called proximity graph is computed, and the cluster border is detected based on the proximity graph. However, the computation of the proximity graph is expensive and the state-of-the-art GPC algorithms on...

We consider elliptic stochastic partial differential equations (SPDEs) with random coefficients and solve them by expanding the solution using generalized polynomial chaos (gPC). Under some mild conditions on the coefficients, the solution is ‘‘sparse’’ in the random space, i.e., only a small number of gPC basis makes considerable contribution to the solution. To exploit this sparsity, we emplo...

Study objectives were to examine the impact of feeding a mixture of choline forms, or a diet high in glycerophosphocholine (GPC) on maternal immune function and offspring growth during lactation. Lactating Sprague-Dawley rat dams (n = 6/diet) were randomized to one of three diets, providing 1 g/kg total choline: Control (100% free choline (FC)), Mixed Choline (MC; 50% phosphatidylcholine (PC), ...

The aim was to determine whether proton magnetic resonance spectroscopy (1H-MRS) of metabolites such as glycerophosphorylcholine (GPC), choline, citrate and lactate in human seminal plasma can be used to differentiate (i) different azoospermic patients and (ii) different forms of spermatogenic failure including those who had undergone radiation therapy or chemotherapy. Semen samples were provid...

The potent anticancer drug actinomycin D (ActD) functions by intercalating into DNA at GpC sites, thereby interrupting essential biological processes including replication and transcription. Certain neurological diseases are correlated with the expansion of (CGG)n trinucleotide sequences, which contain many contiguous GpC sites separated by a single G:G mispair. To characterize the binding of A...

cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the inters...