UNLABELLED Recent advances in high-throughput sequencing technologies have enabled us to sequence large number of cancer samples to reveal novel insights into oncogenetic mechanisms. However, the presence of intratumoral heterogeneity, normal cell contamination and insufficient sequencing depth, together pose a challenge for detecting somatic mutations. Here we propose a fast and an accurate so...

One of the children problems is persistent physical complaints without clear medical cause, that often have a negative effect on children performance. Purpose of this study was investigation of effectiveness of child parent relationship therapy on reducing somatic complaints in children 7 and 8 aged and improving family functioning. Methodology of this study was Quasi-experimental research with...

The relationship between negative affectivity (NA, i.e. the Neuroticism trait and transient distress), self-reported medical condition and somatic complaints was assessed in structural equation models also including personality (the Big Five personality domains), socio-demographic, and health behaviour variables. The results indicated that the individual's current distress level and medical con...

BACKGROUND The Psychiatric Case Register Middle Netherlands (PCR-MN) registers the mental healthcare consumption of over Dutch 760,000 inhabitants in the centre of the Netherlands. In 2010 the follow-up period was over ten years. In this paper we describe the content, aims and research potential of this case register. DESCRIPTION All mental healthcare institutions in the middle-western part o...

The time evolution of the Partridge-Barton model in the presence of the pleiotropic constraint and deleterious somatic mutations is exactly solved for arbitrary fecundity in the context of a matricial formalism. Analytical expressions for the time dependence of the mean survival probabilities are derived. Using the fact that the asymptotic behavior for large time t is controlled by the largest ...

Substitution rates vary between species, and many explanations regarding the causes of this variation have been proposed. Here we consider how new genomic data on the per-generation mutation rate impinge on proposed hypotheses for substitution rate variation in primates. We propose that the generation-time effect as it is usually understood cannot explain the observed rate variation, but instea...