Nanoparticle exposure in pregnancy may result in placental damage and fetotoxicity; however, the factors that determine fetal nanoparticle exposure are unclear. Here we have assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. We determined the placental and fetal uptake of 13 nm gold nanoparticles with diffe...

Radiation therapy (RT) is an integral component of the treatment of many sarcomas and relies on accurate targeting of tumor tissue. Despite conventional treatment planning and RT, local failure rates of 10% to 28% at 5 years have been reported for locally advanced, unresectable sarcomas, due in part to limitations in the cumulative RT dose that may be safely delivered. We describe studies of th...

objective(s): abdominal adhesions are one of the most important problems, occurring after intra-abdominal surgery in more than 90% of cases. this condition is the leading cause of bowel obstruction, infertility, and abdominal/pelvic pain. gold nanoparticles (gnps) have been shown to be non-toxic and exhibit anti-inflammatory, anti-angiogenic and antioxidant activities. the purpose of this study...

In this Letter we report on experimental observation of stimulated low-frequency Raman scattering (SLFRS) in gold and silver nanoparticle suspensions excited by 20 ns ruby laser pulses, SLFRS propagated in forward and backward directions with a maximum conversion efficiency up to 20%. Frequency shift for silver nanoparticle suspension was found to be 0.33 THz and for gold nanoparticle suspensio...

This review gives a brief summary of the field of gold nanoparticle interactions with biological molecules, particularly those with possible catalytic relevance. Gold nanoparticles are well known as catalysts in organic chemistry but much is unknown regarding their potential as catalysts of reactions involving biological molecules such as protein and nucleic acids. Biological molecules may be t...

Metallic nanoparticles of gold functionalized with oligonucleotides conventionally use a terminal thiol modification and have been used in a wide range of applications. Although readily available, the oligonucleotide-nanoparticle conjugates prepared in this way suffer from a lack of stability when exposed to a variety of small molecules or elevated temperatures. If silver is used in place of go...

In this work, thermo-optical properties of gold nanoparticle colloids are studied using continuous wave (CW) laser irradiation at 532 nm. The nanoparticle colloids are fabricated by 18 ns pulsed laser ablation of pure gold plate in the distilled water. The formation of the nanoparticles has been evidenced by optical absorption spectra and transmission electron microscopy. The nonlinear optical ...

metal nanoshells consists of a dielectric core surrounded by a thin noble metal shell, possess unique optical properties, which render nanoshells attractive for use in different technologies. this paper reports a facile method for growth of small gold nanoparticles on the functionalized surface of larger silica nanoparticles. mono-dispersed silica particles and gold nanoparticles were prepared ...

The capture of T7 RNA polymerase using double-stranded promoter DNA on the surface of gold nanoparticles has been demonstrated. The competitive binding and inhibition of T7 RNA polymerase due to specific interactions on the nanoparticle surface represents a transcription factor decoy approach in a model system. The efficiency of inhibition was determined for various nanoparticle sizes, surface ...

in this paper, multi-wall carbon nanotubes (mwcnts), gold nanoparticles (gnp) and glucose oxidase (god) was developed for the specific detection of glucose. mwcnts were chemically modified with the h2so4–hno3 pretreatment to introduce carboxyl groups which were used to interact with the amino groups of poly(allylamine) (paa) and cysteamine via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/n-hy...