We evaluated whether Gonadotrophin releasing hormone incorporation to the Human chorionic gonadotropin protocol improves the sexual response during the natural anestrous season in goats. Thirty-two adult multibreed anovulatory goats (n = 8, four groups), received 20 mg progesterone i.m. on d-1; on d0, all goats received 7.5 mg prostaglandin F i.v. and control group (CG) 0.5 mL of saline i.m., h...

The gonadotropin-releasing hormone (GnRH) receptor is a drug target for certain hormone-dependent diseases such as prostate cancer. In this study, we examined the activation profiles of the endogenous ligand, GnRH and a well-known marketed analog, buserelin using a label-free assay in pituitary αT3-1 cells with endogenous GnRH receptor expression. This whole cell impedance-based technology allo...

Extending the FSH window for multifollicular development by administering FSH from the midfollicular phase onward constitutes a novel mild protocol for ovarian stimulation for in vitro fertilization (IVF) based on the physiology of single dominant follicle selection in normo-ovulatory women. We compared outcomes from this protocol with two other stimulation protocols. One hundred and forty-two ...

The present study was aimed to evaluate the efficiency of estradiol cypionate, benzoate and gonadotropin-releasing hormone during fixed-time artificial insemination (FTAI) protocols in multiparous Murrah buffaloes. A total 35 buffaloes were used between September November 2021 subjected a synchronization protocol. On day 0, insertion an intravaginal progesterone device (CIDR, 1.38 g) made with ...

BACKGROUND Gonadotropin-releasing hormone (GnRH) antagonist protocol has been proposed as a potentially proper option for the patients with limited ovarian reserve. Nevertheless, there is no significant difference in terms of clinical pregnancy between the GnRH antagonist and agonist cycles. The use of aromatase inhibitors such as letrozole was suggested by some studies. OBJECTIVE The object ...

Objectives were to determine the effect of reducing the period of follicle dominance in a timed artificial insemination (AI) protocol on pregnancy per AI (P/AI) in Holstein cows. In experiment 1, 165 cows received 2 injections of PGF(2alpha) at 36 and 50 d in milk (DIM). At 61 DIM, cows were assigned randomly to Cosynch 72 h (CoS72: d 61 GnRH, d 68 PGF(2alpha), d 71 GnRH) or to a 5-d Cosynch 72...

Controlled ovarian stimulation, using a gonadotrophin-releasing hormone (GnRH) antagonist protocol, is a potential treatment option for women with a low response to other fertility treatments as it appears to be at least as effective as GnRH agonists (long protocol). However, previous studies have indicated that the administration of GnRH antagonist may cause an excessive reduction in endogenou...