The JAK/STAT signaling pathway plays important roles in vertebrate development and the regulation of complex cellular processes. Components of the pathway are conserved in Dictyostelium, Caenorhabditis, and Drosophila, yet the complete sequencing and annotation of the D. melanogaster and C. elegans genomes has failed to identify a receptor, raising the possibility that an alternative type of re...

The angiographic changes in neck remnants of ruptured cerebral aneurysms treated with Guglielmi detachable coils (GDCs) were evaluated in the acute stage to analyze the important radiological and clinical factors. The clinical and radiological data of 37 patients with a residual neck of a ruptured cerebral aneurysm treated with GDC were reviewed. The angiographic changes on follow-up angiograph...

The atmospheric properties above three sites (Dome C, Dome A and the South Pole) on the Internal Antarctic Plateau are investigated for astronomical applications using the monthly median of the analyses from ECMWF (the European Centre for Medium-Range Weather Forecasts). Radiosoundings extended on a yearly time scale at the South Pole and Dome C are used to quantify the reliability of the ECMWF...

Architecturally, the Seljuqs' dominion makes a significant shift from the Pre-Islamic Sassanid squinches into a sophisticated transition mechanism employed to change the walls of a square chamber to an octagonal base to set a dome which this initiated a new construction methodology to hybridize the previous experiences of Sassanid domes with new architectural tendencies since the previous under...

Introduction Conclusions References

BACKGROUND The Brugada syndrome is characterized by marked ST-segment elevation in the right precordial ECG leads and is associated with a high incidence of sudden and unexpected arrhythmic death. Our study examines the cellular basis for this syndrome. METHODS AND RESULTS Using arterially perfused wedges of canine right ventricle (RV), we simultaneously recorded transmembrane action potentia...

The dome of the talus is the part that articulates with the ankle mortice formed by the lower articular surfaces of tibia and fibula. A fracture of this part of the talus may be called a dome fracture. Such fractures are not common and the significance of the original radiographic appearance is not always appreciated. Definitive treatment is therefore often unnecessarily delayed ; this has been...