Covering: 1964 to 2013. Bacteria have unusual glycans on their surfaces which distinguish them from the host cells. These unique structures offer avenues for targeting bacteria with specific therapeutics and vaccine. However, these rare sugars are not accessible in acceptable purity and amounts by isolation from natural sources. Thus, procurement of orthogonally protected rare sugar building bl...

The practice of immunization of animals and humans has been carried out for centuries and is generally accepted as the most cost effective and sustainable method of infectious disease control. Over the past 20 years there have been significant changes in our ability to produce antigens by conventional extraction and purification, recombinant DNA and synthesis. However, many of these products ne...

The combination of carbohydrate and lipid generates unusual molecules in which the two distinctive halves of the glycoconjugate influence the function of each other. Membrane glycolipids can act as primary receptors for carbohydrate binding proteins to mediate transmembrane signaling despite restriction to the outer bilayer leaflet. The extensive heterogeneity of the lipid moiety plays a signif...

CONTENTS I N T R O D U C T I O N . COLONIZATION O F THE INTESTINAL TRACT . . T H E GLYCOCONJUGATE CHEMISTRY O F INTESTINAL S U R F A C E S MEMBRANE GLYCOCONJUGATES . . M U C I N GLYCOCONJUGATES . BACTERIAL A D H E S I N S A N D INTESTINAL RECEPTORS . . FIMBRIAL ADHESINS . Type-I fimbriae . Fimbrial serotypes associated with diarrhoea1 disease . Fimbrial adhesins associated with Helicobacter pyl...