نتایج جستجو برای: glutathione s transferase pi

تعداد نتایج: 786180  

1998
Cristina Vega Sinead B. Walsh Timothy J. Mantle

The three-dimensional structure of mouse liver glutathione S-transferase P1-1 carboxymethylated at Cys-47 and its complex with S-(p-nitrobenzyl)glutathione have been determined by x-ray diffraction analysis. The structure of the modified enzyme described here is the first structural report for a Pi class glutathione S-transferase with no glutathione, glutathione S-conjugate, or inhibitor bound....

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2017

Journal: :Cancer research 1991
J A Cook S N Iype J B Mitchell

Monochlorobimane (MCB) has been used as a glutathione (GSH) specific fluorescent probe capable of delineating GSH heterogeneity in cellular systems. Generally, low concentrations of MCB (less than 50 microM) have been used to quantitatively label GSH in rodent cell lines. Incubation of the hamster cell lines, CHO AB1 and V79, with 10 microM MCB labeled 75 and 39% of the reduced GSH pool, respec...

2015
Christina Kaprilian Maria Horti Kosmas Kandilaris Andreas Skolarikos Nikolaos Trakas Ioannis Kastriotis Charalambos Deliveliotis

Multidrug resistance correlates with unfavourable treatment outcomes in numerous cancers including renal cell carcinoma. The expression and clinical relevance of Glutathione-S-transferase-pi (GST-pi), a multidrug resistance factor, in kidney tumors remain controversial. We analyzed the expression of GST-pi in 60 formalin-fixed, paraffin-embedded renal cell carcinoma samples by immunohistochemis...

2015
WEIJIE ZHANG HONGLIANG JIAO XUDONG ZHANG RUIHUA ZHAO FENG WANG WEI HE HONG ZONG QINGXIA FAN LIUXING WANG

The aim of the present study was to investigate the correlation between the expression of DNA (cytosine‑5)‑methyltransferase 1 (DNMT1), glutathione S‑transferase‑P1 (GSTP1) and adenomatous polyposis coli (APC), and the methylation status of GSTP1 and APC in prostate cancer (PCa) and benign prostatic hyperplasia (BPH), and to examine its clinical significance. Immunohistochemistry and reverse tr...

Journal: :The Journal of antibiotics 1993
T Aoyama F Kojima T Yamazaki T Tatee F Abe Y Muraoka H Naganawa T Aoyagi T Takeuchi

Benastatin C, a new member of the benastatins, has been isolated from the culture broth of Streptomyces sp. MI384-DF12. The structure of benastatin C was elucidated as 2-decarboxy-benastatin A by NMR studies. Benastatin D, 2-decarboxybenastatin B, was derived from benastatin B. Benastatins C and D showed inhibitory activities against human pi class glutathione S-transferase (GST pi) and excelle...

Journal: :The Journal of antibiotics 1993
T Aoyama F Kojima F Abe Y Muraoka H Naganawa T Takeuchi T Aoyagi

New benzo[a]naphthacenequinone metabolites, designated bequinostatins A and B, have been isolated from the culture broth of the benastatin-producing strain Streptomyces sp. MI384-DF12. The structures of bequinostatins A and B were determined by spectral analyses to be 5,6,8,13-tetrahydro-1,6,7,9,11-pentahydroxy-8,13-dioxo-3- pentylbenzo[a]naphthacene-2-carboxylic acid and 2-decarboxybequinostat...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2011
Yan Jiang Na Li Pin Dong Niankai Zhang Yan Sun Min Han Junfeng Wen Min Chen

AIM The study was performed to assess the potential role of GSTM1, GSTT1 and GSTP1 polymorphisms in the risk of nasopharyngeal cancer in Chinese population. METHOD We collected 182 cases undergoing pathologic examination and 366 controls from the affiliated hospital of Medical College of Qingdao University from April 2006 to July 2010. Genotyping was based upon duplex polymerase-chain-reactio...

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