There is undoubtedly a close relationship between dietary vitamin E and selenium, but the nature of this is not completely understood. Rotruck et al. (1973) showed that the enzyme glutathione peroxidase (EC 1.1 1.1.9) contains selenium (as an essential cofactor), establishing one of its metabolic roles. Later work established the dependence of tissue glutathione peroxidase activity on dietary s...

There is much evidence suggesting a possible role of reactive oxygen-derived substances in the pathogenesis of both ulcerative colitis and colon cancer. The antioxidant effects of 5-aminosalicylic acid (the active moiety of olsalazine) on induction of colon cancer in an experimental model using 1,2-dimethylhydrazine were studied in male Wistar rats. The levels of reduced glutathione were signif...