نتایج جستجو برای: glutathione
تعداد نتایج: 42065 فیلتر نتایج به سال:
Glutathione transferases are enzymes involved in the detoxification against xenobiotics and noxious compounds. These catalyse a variety of reactions on many physiological xenobiotic compounds using glutathione as co-substrate. Moreover, inhibitors such enzymes. A wide array biosensors based have been developed for analysing compounds, well several devoted to detection quantification themselves....
BACKGROUND Liver cirrhosis is associated with intestinal epithelial barrier dysfunction, which may be affected by oxidative stress. Studies in cirrhotic rats provided evidence for intestinal oxidative stress, but studies in cirrhotic patients are scarce. We have shown intestinal barrier dysfunction in patients with compensated cirrhosis. AIM The present study aimed to investigate whether oxid...
The relation among glutathione-related enzyme activities, thiobarbituric acid-reactive substances of the human aorta and internal mammary artery, and serum lipids was studied in 40 male patients undergoing coronary revascularization. Glutathione peroxidase and glutathione reductase activities were significantly higher in the internal mammary artery, whereas glutathione transferase activity was ...
Glutathione peroxidases are widespread among eukaryotic organisms and function as a major defense against hydrogen peroxide and organic peroxides. However, glutathione peroxidases are not well studied among prokaryotic organisms and have not previously been shown to promote bacterial virulence. Recently, a gene with homology to glutathione peroxidase was shown to contribute to the antioxidant d...
Although ubiquitous, no universal function can be confidently ascribed to glutathione. The eye lens maintains higher concentrations of reduced glutathione within its cells than do other tissues (Waley, 1969). The ratio of protein thiol to reduced glutathione in most species of lens is about 5:1 (Kuck et al., 1982). The requirement for glutathione in maintaining a transparent lens is indicated b...
A single dose of CCl4 (1 ml/kg body weight, po in corn oil) increased the levels of SGOT (serum glutamate oxaloacetate transaminase), SGPT (serum glutamate pyruvate transaminase), LDH (lactate dehydrogenase), glutathione-S-transferase and depletion in reduced glutathione, glutathione peroxidase and glutathione reductase. It also caused enhancement in the levels of lipid peroxidation (LPO) and D...
By isolation of a mixed disulfide product of glutathione and cysteine, glutathione peroxidase was shown to be highly specific for only one donor substrate. Using the coupled assay of NADPH and yeast glutatione reductase, which is highly specific for flutathione disulfide, it was shown that the apparent inhibition of glutathione peroxidase by mercaptoethanol can be described kinetically and that...
Glutathione plays many important roles in biological processes; however, the dynamic changes of glutathione concentrations in living cells remain largely unknown. Here, we report a reversible reaction-based fluorescent probe-designated as RealThiol (RT)-that can quantitatively monitor the real-time glutathione dynamics in living cells. Using RT, we observe enhanced antioxidant capability of act...
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