A remarkable trademark of most tumors is their ability to break down glucose by glycolysis at a vastly higher rate than in normal tissues, even when oxygen is copious. This phenomenon, known as the Warburg effect, enables rapidly dividing tumor cells to generate essential biosynthetic building blocks such as nucleic acids, amino acids, and lipids from glycolytic intermediates to permit growth a...

Abstract IDH mutant gliomas depend on glutaminase for glutamate/glutathione generation from glutamine because R-2-hydroxyglutarate inhibits branched chain amino acid transaminase mediated glutamate biosynthesis. Telaglenastat (CB-839 HCl) is a potent glutaminase-1 specific inhibitor which depletes tumor in orthotopic glioma PDX models and extends survival these when added to radiation/temozolom...

In 1935, Krebs (1) suggested that there may be several glutaminases. A useful preparation of renal ‘Lglutaminase” was described by Archibald (2) ; Greenstein and Carter (3) demonstrated the existence of two types of glutaminases which were activated by a-keto acids and phosphate, respectively. The mechanism of the a-keto acid-activated glutaminases has been demonstrated by Meister and Tice (4),...

L-Glutaminase enzyme was an important enzyme involved in the mineralization of amide forms of nitrogen in the soils. The characteristics of enzyme were determined by these kinetics. The two most remarkable properties of enzymes are their specificity and catalytic efficiency, and it is these properties that enzymes differ in their most strinkingly from simple catalysts. When it is possible to co...