نتایج جستجو برای: glutamic acid decarboxylase

تعداد نتایج: 753728  

Journal: :Journal of immunology 2002
Shawn Winer Igor Astsaturov Roger Gaedigk Denise Hammond-McKibben Marc Pilon Aihua Song Violetta Kubiak Wolfram Karges Enrico Arpaia Colin McKerlie Peter Zucker Bhagirath Singh H-Michael Dosch

ICA69 (islet cell Ag 69 kDa) is a diabetes-associated autoantigen with high expression levels in beta cells and brain. Its function is unknown, but knockout of its Caenorhabditis elegans homologue, ric-19, compromised neurotransmission. We disrupted the murine gene, ica-1, in 129-strain mice. These animals aged normally, but speed-congenic ICA69(null) nonobese diabetic (NOD) mice developed mid-...

Journal: :Journal of immunology 2001
V Judkowski C Pinilla K Schroder L Tucker N Sarvetnick D B Wilson

Nonobese diabetic (NOD) mice spontaneously develop insulitis and destruction of pancreatic islet beta cells similar to type 1 diabetes mellitis in humans. Insulitis also occurs in the BDC2.5 TCR transgenic line of NOD mice that express the rearranged TCR alpha- and beta-chain genes of a diabetogenic NOD CD4 T cell clone. When activated with syngeneic islet cells in culture, BDC2.5 T cells adopt...

Journal: :International Journal of Health Sciences (IJHS) 2022

Autoimmune reaction in Type 1 Diabetes Mellitus (T1DM) is caused by genetic and environmental factors. The genes HLA-DQA1 HLA-DQB1 are strongly associated with T1DM. Other established markers of T1DM were Zinc Transporter 8 Antibody (ZnT8), Glutamic Acid Decarboxylase Antibody-65 (GAD65), C-peptide. This study aims to analyze ZnT8, GAD65, HLA-DQA1, HLA-DQB1, C-peptide Indonesian children A cros...

Journal: :Journal of Pure and Applied Microbiology 2023

Psychobiotics are defined as the organisms that can provide mental health benefit. The possible mechanism of psychobiotics is manipulation neurotransmitter production and by microbes. lactobacillus group has been reported for potential production, especially g-aminobutyric acid (GABA) which an important inhibitory neurotransmitter. Therefore, GABA be used relaxation applied in various psychiatr...

Journal: :Oxygen 2023

Flooding induces low-oxygen stress, which reduces plant growth. The activity of the γ-aminobutyric acid (GABA) shunt is crucial for stress adaptation, in it acts by changing cytosolic pH, limiting reactive oxygen species production, regulating nitrogen metabolism, and bypassing steps tricarboxylic cycle. GABA accumulates under osmotic as well flooding stress. To clarify dynamic roles accumulati...

Journal: :molecular biology research communications 2015
yasaman tavakoli abolghasem esmaeili mohammad rabbani

gamma-amino butyric acid (gaba) possesses several physiological functions such as neurotransmission, induction of hypotension, diuretic and tranquilizer effects. production of gaba-enriched products by lactic acid bacteria has been a focus of different researches in recent years because of their safety and health-promoting specifities. in this study, glutamate decarboxylase (gad) gene of a loca...

Journal: :Journal of neurochemistry 2003
Jordi Serrats Francesc Artigas Guadalupe Mengod Roser Cortés

We have used double-label in situ hybridization techniques to examine the cellular localization of GABAB receptor mRNA in relation to serotonin transporter mRNA and glutamic acid decarboxylase mRNA in the rat dorsal raphe, median raphe and raphe magnus nuclei. The degree of cellular co-localization of these markers notably varied among the different nuclei. In the dorsal raphe, cell bodies show...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1994
A Gutiérrez Z U Khan S J Morris A L De Blas

A selective age-related decrease in both the protein and mRNA levels of the most abundant GABAA receptor subunits has been revealed in the rat inferior colliculus. The number (not affinity) of the native and fully assembled GABAA receptors assayed by 3H-muscimol binding was also decreased (35-49%). The decrease in GABA receptors was accompanied by a decrease in the protein and mRNA of the GABA-...

Journal: :The Journal of comparative neurology 2000
L T Nguyen N M Grzywacz

Acetylcholine and gamma -aminobutyric acid (GABA) are putative neurotransmitters in the adult vertebrate retina. In this study, cells that coexpress choline acetyltransferase (ChAT) and GABA or glutamic acid decarboxylase (GAD) were investigated in turtle retinas from stage 14 (S14) to adulthood by using a double-labeling immunofluorescence technique. ChAT immunoreactivity was observed at S15 a...

Journal: :Endocrinology 2005
Nancy K Mueller Shi Di Charles M Paden James P Herman

Confocal microscopy was used to assess activity-dependent neuroplasticity in neurotransmitter innervation of vasopressin immunoreactive magnocellular neurons in the supraoptic nucleus (SON). Vesicular glutamate transporter 2, glutamic acid decarboxylase, and dopamine beta-hydroxylase (DBH) synaptic boutons were visualized in apposition to vasopressin neurons in the SON. A decrease in DBH synapt...

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