Abstract Background Brain metastases (BM) are the most frequent neoplasm in central nervous system (CNS) and primary tumors frequently involved melanoma, lung cancer breast cancer. CNS localisation is associated with poor prognosis, stereotactic radiosurgery (SRS) represents a treatment option for patients good performance status. Glutamate (Glu) neurotransmitter which plays facilitating role c...

We studied the hepatotoxic effects of a deltamethrin containing formulation (Decis®) on developing em-bryo of Gallus domesticus. Fertilized eggs were immersed in three different concentrations of deltamethrin (12.5, 25 and 50 mg/L) for 60 min at 37 ˚C prior to incubation (ED 0) and on the 4th day of incubation (ED 4) and incubated till embryonic day (ED) 16. Exposure to 50 mg/L of deltamethrin ...

The agents of meningopneumonitis (MN) and of trachoma (TR) purified from chick embryo allantoic fluids and yolk sacs, respectively, were shown to produce CO(2) from the C(1) positions of pyruvate and glutamate, but not from the other carbon atoms. The reaction with pyruvate did not require did not require the addition of cofactors, but was stimulated to a small extent by alpha-lipoic acid and, ...


 Aim: The present study was carried out to determine the protective potential of Lycopene enriched tomato extract (LycT) against hepatic and renal damage caused in mice by dexamethasone administration.
 Study Design: Male LACA were randomly divided into four treatment groups (n=6-7 animals per group) depending upon they received. Group I (control) served as control orally administere...

Consumption of foods enriched with herbs and herbal medicine products are highly popular. Their current popularity renders the assessment their safety an urgent necessity, they must figure prominently in nutritional surveys as possible factors cancer some other diseases, may contain toxic chemicals heavy metals addition to natural organic toxins, made present study aims investigate side effects...

we studied the hepatotoxic effects of a deltamethrin containing formulation (decis®) on developing em-bryo of gallus domesticus. fertilized eggs were immersed in three different concentrations of deltamethrin (12.5, 25 and 50 mg/l) for 60 min at 37 ˚c prior to incubation (ed 0) and on the 4th day of incubation (ed 4) and incubated till embryonic day (ed) 16. exposure to 50 mg/l of deltamethrin ...

In Bacillus sphaericus and other Bacillus spp., D-amino acid transaminase has been considered solely responsible for biosynthesis of D-glutamate, an essential component of cell wall peptidoglycan, in contrast to the glutamate racemase employed by many other bacteria. We report here the cloning of the dat gene encoding D-amino acid transaminase and the glr gene encoding a glutamate racemase from...

The hepatoprotective activity of the ethanolic extract of the rhizomes of Costus speciosus (Koenig) Sm. was studied on carbon tetrachloride treated rats. The extract registered a significant fall in the levels of serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), serum bilirubin (SBLN) and liver inflammation supported by...

Early, rapid effects of glucagon on glutamate metabolism were studied in rat livers perfused with bicarbonate buffer containing bovine albumin and red cells, [14C]glutamate in tracer amounts, and physiological levels of lactate and pyruvate. Glucagon increased [Wlglucose synthesis from [W]glutamate to a greater extent than from other labeled substrates. The effect was maximal at 3 min and was n...